PDB 4x2t

PDB Information

PDB4X2T
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourcePlasmodium falciparum (isolate 3D7)
Primary Citation
X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17.
Drinkwater, N., Bamert, R.S., Sivaraman, K.K., Paiardini, A., McGowan, S.
Proteins
HeaderHydrolase/Hydrolase Inhibitor
Released2014-11-27
Resolution2.730
CATH Insert Date28 Jun, 2015

PDB Images (37)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped
C 29 Jun, 2015 Chopped
D 29 Jun, 2015 Chopped
E 29 Jun, 2015 Chopped
F 29 Jun, 2015 Chopped
G 29 Jun, 2015 Chopped
H 29 Jun, 2015 Chopped
I 29 Jun, 2015 Chopped
J 29 Jun, 2015 Chopped
K 29 Jun, 2015 Chopped
L 29 Jun, 2015 Chopped

CATH Domains (24)

Domain ID Date inserted into CATH Superfamily CATH Status
4x2tA01 22 Jul, 2015 3.40.220.10 Assigned
4x2tA02 22 Jul, 2015 3.40.630.10 Assigned
4x2tB01 22 Jul, 2015 3.40.220.10 Assigned
4x2tB02 22 Jul, 2015 3.40.630.10 Assigned
4x2tC01 22 Jul, 2015 3.40.220.10 Assigned
4x2tC02 22 Jul, 2015 3.40.630.10 Assigned
4x2tD01 22 Jul, 2015 3.40.220.10 Assigned
4x2tD02 22 Jul, 2015 3.40.630.10 Assigned
4x2tE01 22 Jul, 2015 3.40.220.10 Assigned
4x2tE02 22 Jul, 2015 3.40.630.10 Assigned
4x2tF01 22 Jul, 2015 3.40.220.10 Assigned
4x2tF02 22 Jul, 2015 3.40.630.10 Assigned
4x2tG01 22 Jul, 2015 3.40.220.10 Assigned
4x2tG02 22 Jul, 2015 3.40.630.10 Assigned
4x2tH01 22 Jul, 2015 3.40.220.10 Assigned
4x2tH02 22 Jul, 2015 3.40.630.10 Assigned
4x2tI01 20 Jul, 2015 3.40.220.10 Assigned
4x2tI02 20 Jul, 2015 3.40.630.10 Assigned
4x2tJ01 22 Jul, 2015 3.40.220.10 Assigned
4x2tJ02 22 Jul, 2015 3.40.630.10 Assigned
4x2tK01 22 Jul, 2015 3.40.220.10 Assigned
4x2tK02 22 Jul, 2015 3.40.630.10 Assigned
4x2tL01 22 Jul, 2015 3.40.220.10 Assigned
4x2tL02 22 Jul, 2015 3.40.630.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q8IL11 Q8IL11_PLAF7 Plasmodium falciparum 3D7 M17 leucyl aminopeptidase
Q8IL11 Q8IL11_PLAF7 Plasmodium falciparum 3D7 M17 leucyl aminopeptidase
Q8IL11 Q8IL11_PLAF7 Plasmodium falciparum 3D7 M17 leucyl aminopeptidase
Q8IL11 Q8IL11_PLAF7 Plasmodium falciparum 3D7 M17 leucyl aminopeptidase
Q8IL11 Q8IL11_PLAF7 Plasmodium falciparum 3D7 M17 leucyl aminopeptidase
Q8IL11 Q8IL11_PLAF7 Plasmodium falciparum 3D7 M17 leucyl aminopeptidase
Q8IL11 Q8IL11_PLAF7 Plasmodium falciparum 3D7 M17 leucyl aminopeptidase
Q8IL11 Q8IL11_PLAF7 Plasmodium falciparum 3D7 M17 leucyl aminopeptidase
Q8IL11 Q8IL11_PLAF7 Plasmodium falciparum 3D7 M17 leucyl aminopeptidase
Q8IL11 Q8IL11_PLAF7 Plasmodium falciparum 3D7 M17 leucyl aminopeptidase
Q8IL11 Q8IL11_PLAF7 Plasmodium falciparum 3D7 M17 leucyl aminopeptidase
Q8IL11 Q8IL11_PLAF7 Plasmodium falciparum 3D7 M17 leucyl aminopeptidase