PDB 4wz8

PDB Information

PDB4WZ8
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceSaccharomyces cerevisiae
Primary Citation
Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes.
Griffith, D.A., Kung, D.W., Esler, W.P., Amor, P.A., Bagley, S.W., Beysen, C., Carvajal-Gonzalez, S., Doran, S.D., Limberakis, C., Mathiowetz, A.M., McPherson, K., Price, D.A., Ravussin, E., Sonnenberg, G.E., Southers, J.A., Sweet, L.J., Turner, S.M., Vajdos, F.F.
J.Med.Chem.
HeaderLigase/Ligase Inhibitor
Released2014-11-18
Resolution2.230
CATH Insert Date21 Dec, 2014

PDB Images (9)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
B 22 Dec, 2014 Chopped
C 22 Dec, 2014 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
4wz8B01 28 Dec, 2014 3.90.226.10 Assigned
4wz8B02 28 Dec, 2014 2.40.460.10 Assigned
4wz8B03 28 Dec, 2014 3.90.226.10 Assigned
4wz8C01 28 Dec, 2014 3.90.226.10 Assigned
4wz8C02 28 Dec, 2014 2.40.460.10 Assigned
4wz8C03 28 Dec, 2014 3.90.226.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q00955 ACAC_YEAST Saccharomyces cerevisiae S288C Acetyl-CoA carboxylase
Q00955 ACAC_YEAST Saccharomyces cerevisiae S288C Acetyl-CoA carboxylase