PDB 4wcf

PDB Information

PDB4WCF
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceTrypanosoma brucei brucei
Primary Citation
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.
Linciano, P., Dawson, A., Pohner, I., Costa, D.M., Sa, M.S., Cordeiro-da-Silva, A., Luciani, R., Gul, S., Witt, G., Ellinger, B., Kuzikov, M., Gribbon, P., Reinshagen, J., Wolf, M., Behrens, B., Hannaert, V., Michels, P.A.M., Nerini, E., Pozzi, C., di Pisa, F., Landi, G., Santarem, N., Ferrari, S., Saxena, P., Lazzari, S., Cannazza, G., Freitas-Junior, L.H., Moraes, C.B., Pascoalino, B.S., Alcantara, L.M., Bertolacini, C.P., Fontana, V., Wittig, U., Muller, W., Wade, R.C., Hunter, W.N., Mangani, S., Costantino, L., Costi, M.P.
ACS Omega
HeaderOxidoreductase
Released2014-09-04
Resolution1.930
CATH Insert Date04 Oct, 2015

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 05 Oct, 2015 Chopped
B 05 Oct, 2015 Chopped
C 05 Oct, 2015 Chopped
D 05 Oct, 2015 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4wcfA00 01 Nov, 2015 3.40.50.720 Assigned
4wcfB00 01 Nov, 2015 3.40.50.720 Assigned
4wcfC00 31 Oct, 2015 3.40.50.720 Assigned
4wcfD00 01 Nov, 2015 3.40.50.720 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
O76290 O76290_TRYBB Trypanosoma brucei brucei Pteridine reductase
O76290 O76290_TRYBB Trypanosoma brucei brucei Pteridine reductase
O76290 O76290_TRYBB Trypanosoma brucei brucei Pteridine reductase
O76290 O76290_TRYBB Trypanosoma brucei brucei Pteridine reductase