PDB 4w9e
PDB Information
| PDB | 4W9E |
| Method | X-RAY DIFFRACTION |
| Host Organism | Escherichia coli BL21(DE3) |
| Gene Source | Homo sapiens |
| Primary Citation | Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
J.Med.Chem.
|
| Header | Ligase |
| Released | 2014-08-27 |
| Resolution | 2.600 |
| CATH Insert Date | 14 Sep, 2014 |
PDB Images (29)
4w9e
PDB 4w9e
4w9eA
PDB Chain 4w9eA
4w9eB
PDB Chain 4w9eB
4w9eC
PDB Chain 4w9eC
4w9eD
PDB Chain 4w9eD
4w9eE
PDB Chain 4w9eE
4w9eF
PDB Chain 4w9eF
4w9eG
PDB Chain 4w9eG
4w9eH
PDB Chain 4w9eH
4w9eI
PDB Chain 4w9eI
4w9eJ
PDB Chain 4w9eJ
4w9eK
PDB Chain 4w9eK
4w9eL
PDB Chain 4w9eL
4w9eA00
CATH Domain 4w9eA00
4w9eB00
CATH Domain 4w9eB00
4w9eC01
CATH Domain 4w9eC01
4w9eC02
CATH Domain 4w9eC02
4w9eD00
CATH Domain 4w9eD00
4w9eE00
CATH Domain 4w9eE00
4w9eF01
CATH Domain 4w9eF01
4w9eF02
CATH Domain 4w9eF02
4w9eG00
CATH Domain 4w9eG00
4w9eH00
CATH Domain 4w9eH00
4w9eI01
CATH Domain 4w9eI01
4w9eI02
CATH Domain 4w9eI02
4w9eJ00
CATH Domain 4w9eJ00
4w9eK00
CATH Domain 4w9eK00
4w9eL01
CATH Domain 4w9eL01
4w9eL02
CATH Domain 4w9eL02
PDB Prints
PDB Chains (12)
| Chain ID | Date inserted into CATH | CATH Status |
|---|---|---|
| A | 15 Sep, 2014 | Chopped |
| B | 15 Sep, 2014 | Chopped |
| C | 15 Sep, 2014 | Chopped |
| D | 15 Sep, 2014 | Chopped |
| E | 15 Sep, 2014 | Chopped |
| F | 15 Sep, 2014 | Chopped |
| G | 15 Sep, 2014 | Chopped |
| H | 15 Sep, 2014 | Chopped |
| I | 15 Sep, 2014 | Chopped |
| J | 15 Sep, 2014 | Chopped |
| K | 15 Sep, 2014 | Chopped |
| L | 15 Sep, 2014 | Chopped |
CATH Domains (16)
| Domain ID | Date inserted into CATH | Superfamily | CATH Status |
|---|---|---|---|
| 4w9eA00 | 16 Sep, 2014 | 3.10.20.90 | Assigned |
| 4w9eB00 | 16 Sep, 2014 | 3.30.710.10 | Assigned |
| 4w9eC01 | 16 Sep, 2014 | 2.60.40.780 | Assigned |
| 4w9eC02 | 16 Sep, 2014 | 1.10.750.10 | Assigned |
| 4w9eD00 | 16 Sep, 2014 | 3.10.20.90 | Assigned |
| 4w9eE00 | 16 Sep, 2014 | 3.30.710.10 | Assigned |
| 4w9eF01 | 16 Sep, 2014 | 2.60.40.780 | Assigned |
| 4w9eF02 | 16 Sep, 2014 | 1.10.750.10 | Assigned |
| 4w9eG00 | 16 Sep, 2014 | 3.10.20.90 | Assigned |
| 4w9eH00 | 16 Sep, 2014 | 3.30.710.10 | Assigned |
| 4w9eI01 | 16 Sep, 2014 | 2.60.40.780 | Assigned |
| 4w9eI02 | 16 Sep, 2014 | 1.10.750.10 | Assigned |
| 4w9eJ00 | 16 Sep, 2014 | 3.10.20.90 | Assigned |
| 4w9eK00 | 16 Sep, 2014 | 3.30.710.10 | Assigned |
| 4w9eL01 | 16 Sep, 2014 | 2.60.40.780 | Assigned |
| 4w9eL02 | 16 Sep, 2014 | 1.10.750.10 | Assigned |
UniProtKB Entries (12)
| Accession | Gene ID | Taxon | Description |
|---|---|---|---|
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
