PDB 4uyg

PDB Information

PDB4UYG
MethodX-RAY DIFFRACTION
Host OrganismESCHERICHIA COLI
Gene SourceHOMO SAPIENS
Primary Citation
The Discovery of I-Bet726 (Gsk1324726A), a Potent Tetrahydroquinoline Apoa1 Up-Regulator and Selective Bet Bromodomain Inhibitor.
Gosmini, R., Nguyen, V.L., Toum, J., Simon, C., Brusq, J.M., Krysa, G., Mirguet, O., Riou-Eymard, A.M., Boursier, E.V., Trottet, L., Bamborough, P., Clark, H., Chung, C.W., Cutler, L., Demont, E.H., Kaur, R., Lewis, A.J., Schilling, M.B., Soden, P.E., Taylor, S., Walker, A.L., Walker, M.D., Prinjha, R.K., Nicodeme, E.
J.Med.Chem.
HeaderTranscription
Released2014-08-31
Resolution2.500
CATH Insert Date19 Oct, 2014

PDB Images (13)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 20 Oct, 2014 Chopped
B 20 Oct, 2014 Chopped
C 20 Oct, 2014 Chopped
D 20 Oct, 2014 Chopped
E 20 Oct, 2014 Chopped
F 20 Oct, 2014 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
4uygA00 21 Oct, 2014 1.20.920.10 Assigned
4uygB00 21 Oct, 2014 1.20.920.10 Assigned
4uygC00 21 Oct, 2014 1.20.920.10 Assigned
4uygD00 21 Oct, 2014 1.20.920.10 Assigned
4uygE00 21 Oct, 2014 1.20.920.10 Assigned
4uygF00 21 Oct, 2014 1.20.920.10 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
P25440 BRD2_HUMAN Homo sapiens Bromodomain-containing protein 2
P25440 BRD2_HUMAN Homo sapiens Bromodomain-containing protein 2
P25440 BRD2_HUMAN Homo sapiens Bromodomain-containing protein 2
P25440 BRD2_HUMAN Homo sapiens Bromodomain-containing protein 2
P25440 BRD2_HUMAN Homo sapiens Bromodomain-containing protein 2
P25440 BRD2_HUMAN Homo sapiens Bromodomain-containing protein 2