PDB 4tzr

PDB Information

PDB4TZR
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceToxoplasma gondii
Primary Citation
Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.
Vidadala, R.S., Rivas, K.L., Ojo, K.K., Hulverson, M.A., Zambriski, J.A., Bruzual, I., Schultz, T.L., Huang, W., Zhang, Z., Scheele, S., DeRocher, A.E., Choi, R., Barrett, L.K., Siddaramaiah, L.K., Hol, W.G., Fan, E., Merritt, E.A., Parsons, M., Freiberg, G., Marsh, K., Kempf, D.J., Carruthers, V.B., Isoherranen, N., Doggett, J.S., Van Voorhis, W.C., Maly, D.J.
J. Med. Chem.
HeaderTransferase
Released2014-07-10
Resolution2.000
CATH Insert Date07 Sep, 2014

PDB Images (5)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 08 Sep, 2014 Chopped

CATH Domains (3)

Domain ID Date inserted into CATH Superfamily CATH Status
4tzrA01 10 Sep, 2014 3.30.200.20 Assigned
4tzrA02 10 Sep, 2014 1.10.510.10 Assigned
4tzrA03 10 Sep, 2014 Holding pen

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q9BJF5 Q9BJF5_TOXGO Toxoplasma gondii Calmodulin-domain protein kinase 1