PDB 4tn4

PDB Information

PDB4TN4
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourcePlasmodium vivax
Primary Citation
Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT): Cocrystal Structures of Pyrazolopyrans with Potent Blood- and Liver-Stage Activities.
Witschel, M.C., Rottmann, M., Schwab, A., Leartsakulpanich, U., Chitnumsub, P., Seet, M., Tonazzi, S., Schwertz, G., Stelzer, F., Mietzner, T., McNamara, C., Thater, F., Freymond, C., Jaruwat, A., Pinthong, C., Riangrungroj, P., Oufir, M., Hamburger, M., Maser, P., Sanz-Alonso, L.M., Charman, S., Wittlin, S., Yuthavong, Y., Chaiyen, P., Diederich, F.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2014-06-03
Resolution2.200
CATH Insert Date28 Jun, 2015

PDB Images (10)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped
C 29 Jun, 2015 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
4tn4A01 15 Jul, 2015 3.90.1150.10 Assigned
4tn4A02 15 Jul, 2015 3.40.640.10 Assigned
4tn4B01 15 Jul, 2015 3.90.1150.10 Assigned
4tn4B02 15 Jul, 2015 3.40.640.10 Assigned
4tn4C01 15 Jul, 2015 3.90.1150.10 Assigned
4tn4C02 15 Jul, 2015 3.40.640.10 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
A5K8L9 A5K8L9_PLAVS Plasmodium vivax Sal-1 Serine hydroxymethyltransferase, putative
A5K8L9 A5K8L9_PLAVS Plasmodium vivax Sal-1 Serine hydroxymethyltransferase, putative
A5K8L9 A5K8L9_PLAVS Plasmodium vivax Sal-1 Serine hydroxymethyltransferase, putative