PDB Information

PDB4RX0
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourcePlasmodium falciparum
Primary Citation
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.
Phillips, M.A., Lotharius, J., Marsh, K., White, J., Dayan, A., White, K.L., Njoroge, J.W., El Mazouni, F., Lao, Y., Kokkonda, S., Tomchick, D.R., Deng, X., Laird, T., Bhatia, S.N., March, S., Ng, C.L., Fidock, D.A., Wittlin, S., Lafuente-Monasterio, M., Benito, F.J., Alonso, L.M., Martinez, M.S., Jimenez-Diaz, M.B., Bazaga, S.F., Angulo-Barturen, I., Haselden, J.N., Louttit, J., Cui, Y., Sridhar, A., Zeeman, A.M., Kocken, C., Sauerwein, R., Dechering, K., Avery, V.M., Duffy, S., Delves, M., Sinden, R., Ruecker, A., Wickham, K.S., Rochford, R., Gahagen, J., Iyer, L., Riccio, E., Mirsalis, J., Bathhurst, I., Rueckle, T., Ding, X., Campo, B., Leroy, D., Rogers, M.J., Rathod, P.K., Burrows, J.N., Charman, S.A.
Sci Transl Med
HeaderOxidoreductase/Oxidoreductase Inhibitor
Released2014-12-08
Resolution2.250
CATH Insert Date16 Aug, 2015

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 17 Aug, 2015 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
4rx0A00 19 Aug, 2015 3.20.20.70 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q08210 PYRD_PLAF7 Plasmodium falciparum 3D7 Dihydroorotate dehydrogenase (quinone), mitochondrial
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