PDB 4r95

PDB Links
Overview

PDB Information

PDB	4R95
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of potent iminoheterocycle BACE1 inhibitors. Caldwell, J.P., Mazzola, R.D., Durkin, J., Chen, J., Chen, X., Favreau, L., Kennedy, M., Kuvelkar, R., Lee, J., McHugh, N., McKittrick, B., Orth, P., Stamford, A., Strickland, C., Voigt, J., Wang, L., Zhang, L., Zhang, Q., Zhu, Z. Bioorg.Med.Chem.Lett.
Header	Hydrolase/Hydrolase Inhibitor
Released	2014-09-03
Resolution	1.990
CATH Insert Date	16 Nov, 2014

PDB Images (7)

Image of CATH 4r95

4r95

PDB 4r95

Image of CATH 4r95A

4r95A

PDB Chain 4r95A

Image of CATH 4r95B

4r95B

PDB Chain 4r95B

Image of CATH 4r95A01

4r95A01

CATH Domain 4r95A01

Image of CATH 4r95A02

4r95A02

CATH Domain 4r95A02

Image of CATH 4r95B01

4r95B01

CATH Domain 4r95B01

Image of CATH 4r95B02

4r95B02

CATH Domain 4r95B02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	17 Nov, 2014	Chopped
B	17 Nov, 2014	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4r95A01	19 Nov, 2014	2.40.70.10	Assigned
4r95A02	19 Nov, 2014	2.40.70.10	Assigned
4r95B01	19 Nov, 2014	2.40.70.10	Assigned
4r95B02	19 Nov, 2014	2.40.70.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1