PDB 4r92

PDB Links
Overview

PDB Information

PDB	4R92
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of potent iminoheterocycle BACE1 inhibitors. Caldwell, J.P., Mazzola, R.D., Durkin, J., Chen, J., Chen, X., Favreau, L., Kennedy, M., Kuvelkar, R., Lee, J., McHugh, N., McKittrick, B., Orth, P., Stamford, A., Strickland, C., Voigt, J., Wang, L., Zhang, L., Zhang, Q., Zhu, Z. Bioorg.Med.Chem.Lett.
Header	Hydrolase/Hydrolase Inhibitor
Released	2014-09-03
Resolution	1.710
CATH Insert Date	16 Nov, 2014

PDB Images (7)

Image of CATH 4r92

4r92

PDB 4r92

Image of CATH 4r92A

4r92A

PDB Chain 4r92A

Image of CATH 4r92B

4r92B

PDB Chain 4r92B

Image of CATH 4r92A01

4r92A01

CATH Domain 4r92A01

Image of CATH 4r92A02

4r92A02

CATH Domain 4r92A02

Image of CATH 4r92B01

4r92B01

CATH Domain 4r92B01

Image of CATH 4r92B02

4r92B02

CATH Domain 4r92B02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	17 Nov, 2014	Chopped
B	17 Nov, 2014	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4r92A01	19 Nov, 2014	2.40.70.10	Assigned
4r92A02	19 Nov, 2014	2.40.70.10	Assigned
4r92B01	19 Nov, 2014	2.40.70.10	Assigned
4r92B02	19 Nov, 2014	2.40.70.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1