PDB 4r91

PDB Links
Overview

PDB Information

PDB	4R91
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of potent iminoheterocycle BACE1 inhibitors. Caldwell, J.P., Mazzola, R.D., Durkin, J., Chen, J., Chen, X., Favreau, L., Kennedy, M., Kuvelkar, R., Lee, J., McHugh, N., McKittrick, B., Orth, P., Stamford, A., Strickland, C., Voigt, J., Wang, L., Zhang, L., Zhang, Q., Zhu, Z. Bioorg.Med.Chem.Lett.
Header	Hydrolase/Hydrolase Inhibitor
Released	2014-09-03
Resolution	1.580
CATH Insert Date	16 Nov, 2014

PDB Images (7)

Image of CATH 4r91

4r91

PDB 4r91

Image of CATH 4r91A

4r91A

PDB Chain 4r91A

Image of CATH 4r91B

4r91B

PDB Chain 4r91B

Image of CATH 4r91A01

4r91A01

CATH Domain 4r91A01

Image of CATH 4r91A02

4r91A02

CATH Domain 4r91A02

Image of CATH 4r91B01

4r91B01

CATH Domain 4r91B01

Image of CATH 4r91B02

4r91B02

CATH Domain 4r91B02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	17 Nov, 2014	Chopped
B	17 Nov, 2014	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4r91A01	19 Nov, 2014	2.40.70.10	Assigned
4r91A02	19 Nov, 2014	2.40.70.10	Assigned
4r91B01	19 Nov, 2014	2.40.70.10	Assigned
4r91B02	19 Nov, 2014	2.40.70.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1