PDB 4r18

PDB Links
Overview

PDB Information

PDB	4R18
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site. Dubiella, C., Cui, H., Gersch, M., Brouwer, A.J., Sieber, S.A., Kruger, A., Liskamp, R.M., Groll, M. Angew.Chem.Int.Ed.Engl.
Header	Hydrolase/Hydrolase Inhibitor
Released	2014-08-04
Resolution	2.400
CATH Insert Date	26 Oct, 2014

PDB Images (57)

4r18

PDB 4r18

4r18a

PDB Chain 4r18a

4r18A

PDB Chain 4r18A

4r18b

PDB Chain 4r18b

4r18B

PDB Chain 4r18B

4r18C

PDB Chain 4r18C

4r18D

PDB Chain 4r18D

4r18E

PDB Chain 4r18E

4r18F

PDB Chain 4r18F

4r18G

PDB Chain 4r18G

4r18H

PDB Chain 4r18H

4r18I

PDB Chain 4r18I

4r18J

PDB Chain 4r18J

4r18K

PDB Chain 4r18K

4r18L

PDB Chain 4r18L

4r18M

PDB Chain 4r18M

4r18N

PDB Chain 4r18N

4r18O

PDB Chain 4r18O

4r18P

PDB Chain 4r18P

4r18Q

PDB Chain 4r18Q

4r18R

PDB Chain 4r18R

4r18S

PDB Chain 4r18S

4r18T

PDB Chain 4r18T

4r18U

PDB Chain 4r18U

4r18V

PDB Chain 4r18V

4r18W

PDB Chain 4r18W

4r18X

PDB Chain 4r18X

4r18Y

PDB Chain 4r18Y

4r18Z

PDB Chain 4r18Z

4r18a00

CATH Domain 4r18a00

4r18A00

CATH Domain 4r18A00

4r18b00

CATH Domain 4r18b00

4r18B00

CATH Domain 4r18B00

4r18C00

CATH Domain 4r18C00

4r18D00

CATH Domain 4r18D00

4r18E00

CATH Domain 4r18E00

4r18F00

CATH Domain 4r18F00

4r18G00

CATH Domain 4r18G00

4r18H00

CATH Domain 4r18H00

4r18I00

CATH Domain 4r18I00

4r18J00

CATH Domain 4r18J00

4r18K00

CATH Domain 4r18K00

4r18L00

CATH Domain 4r18L00

4r18M00

CATH Domain 4r18M00

4r18N00

CATH Domain 4r18N00

4r18O00

CATH Domain 4r18O00

4r18P00

CATH Domain 4r18P00

4r18Q00

CATH Domain 4r18Q00

4r18R00

CATH Domain 4r18R00

4r18S00

CATH Domain 4r18S00

4r18T00

CATH Domain 4r18T00

4r18U00

CATH Domain 4r18U00

4r18V00

CATH Domain 4r18V00

4r18W00

CATH Domain 4r18W00

4r18X00

CATH Domain 4r18X00

4r18Y00

CATH Domain 4r18Y00

4r18Z00

CATH Domain 4r18Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	27 Oct, 2014	Chopped
A	27 Oct, 2014	Chopped
b	27 Oct, 2014	Chopped
B	27 Oct, 2014	Chopped
C	27 Oct, 2014	Chopped
D	27 Oct, 2014	Chopped
E	27 Oct, 2014	Chopped
F	27 Oct, 2014	Chopped
G	27 Oct, 2014	Chopped
H	27 Oct, 2014	Chopped
I	27 Oct, 2014	Chopped
J	27 Oct, 2014	Chopped
K	27 Oct, 2014	Chopped
L	27 Oct, 2014	Chopped
M	27 Oct, 2014	Chopped
N	27 Oct, 2014	Chopped
O	27 Oct, 2014	Chopped
P	27 Oct, 2014	Chopped
Q	27 Oct, 2014	Chopped
R	27 Oct, 2014	Chopped
S	27 Oct, 2014	Chopped
T	27 Oct, 2014	Chopped
U	27 Oct, 2014	Chopped
V	27 Oct, 2014	Chopped
W	27 Oct, 2014	Chopped
X	27 Oct, 2014	Chopped
Y	27 Oct, 2014	Chopped
Z	27 Oct, 2014	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4r18a00	02 Nov, 2014	3.60.20.10	Assigned
4r18A00	02 Nov, 2014	3.60.20.10	Assigned
4r18b00	02 Nov, 2014	3.60.20.10	Assigned
4r18B00	02 Nov, 2014	3.60.20.10	Assigned
4r18C00	02 Nov, 2014	3.60.20.10	Assigned
4r18D00	02 Nov, 2014	3.60.20.10	Assigned
4r18E00	02 Nov, 2014	3.60.20.10	Assigned
4r18F00	02 Nov, 2014	3.60.20.10	Assigned
4r18G00	02 Nov, 2014	3.60.20.10	Assigned
4r18H00	02 Nov, 2014	3.60.20.10	Assigned
4r18I00	02 Nov, 2014	3.60.20.10	Assigned
4r18J00	02 Nov, 2014	3.60.20.10	Assigned
4r18K00	02 Nov, 2014	3.60.20.10	Assigned
4r18L00	02 Nov, 2014	3.60.20.10	Assigned
4r18M00	02 Nov, 2014	3.60.20.10	Assigned
4r18N00	02 Nov, 2014	3.60.20.10	Assigned
4r18O00	02 Nov, 2014	3.60.20.10	Assigned
4r18P00	02 Nov, 2014	3.60.20.10	Assigned
4r18Q00	02 Nov, 2014	3.60.20.10	Assigned
4r18R00	02 Nov, 2014	3.60.20.10	Assigned
4r18S00	02 Nov, 2014	3.60.20.10	Assigned
4r18T00	02 Nov, 2014	3.60.20.10	Assigned
4r18U00	02 Nov, 2014	3.60.20.10	Assigned
4r18V00	02 Nov, 2014	3.60.20.10	Assigned
4r18W00	02 Nov, 2014	3.60.20.10	Assigned
4r18X00	02 Nov, 2014	3.60.20.10	Assigned
4r18Y00	02 Nov, 2014	3.60.20.10	Assigned
4r18Z00	02 Nov, 2014	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4