PDB 4qo8

PDB Information

PDB4QO8
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.
Dragovich, P.S., Fauber, B.P., Boggs, J., Chen, J., Corson, L.B., Ding, C.Z., Eigenbrot, C., Ge, H., Giannetti, A.M., Hunsaker, T., Labadie, S., Li, C., Liu, Y., Liu, Y., Ma, S., Malek, S., Peterson, D., Pitts, K.E., Purkey, H.E., Robarge, K., Salphati, L., Sideris, S., Ultsch, M., VanderPorten, E., Wang, J., Wei, B., Xu, Q., Yen, I., Yue, Q., Zhang, H., Zhang, X., Zhou, A.
Bioorg.Med.Chem.Lett.
HeaderOxidoreductase/Oxidoreductase Inhibitor
Released2014-06-19
Resolution2.000
CATH Insert Date27 Jul, 2014

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 28 Jul, 2014 Chopped
B 28 Jul, 2014 Chopped
C 28 Jul, 2014 Chopped
D 28 Jul, 2014 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4qo8A01 03 Aug, 2014 3.40.50.720 Assigned
4qo8A02 03 Aug, 2014 3.90.110.10 Assigned
4qo8B01 03 Aug, 2014 3.40.50.720 Assigned
4qo8B02 03 Aug, 2014 3.90.110.10 Assigned
4qo8C01 03 Aug, 2014 3.40.50.720 Assigned
4qo8C02 03 Aug, 2014 3.90.110.10 Assigned
4qo8D01 03 Aug, 2014 3.40.50.720 Assigned
4qo8D02 03 Aug, 2014 3.90.110.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain