PDB 4qlu

PDB Links
Overview

PDB Information

PDB	4QLU
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes De Bruin, G., Huber, E.M., Xin, B.T., Van Rooden, E.J., Al-Ayed, K., Kim, K.B., Kisselev, A.F., Driessen, C., Van der Stelt, M., Van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2014-06-13
Resolution	2.800
CATH Insert Date	10 Aug, 2014

PDB Images (57)

4qlu

PDB 4qlu

4qlua

PDB Chain 4qlua

4qluA

PDB Chain 4qluA

4qlub

PDB Chain 4qlub

4qluB

PDB Chain 4qluB

4qluC

PDB Chain 4qluC

4qluD

PDB Chain 4qluD

4qluE

PDB Chain 4qluE

4qluF

PDB Chain 4qluF

4qluG

PDB Chain 4qluG

4qluH

PDB Chain 4qluH

4qluI

PDB Chain 4qluI

4qluJ

PDB Chain 4qluJ

4qluK

PDB Chain 4qluK

4qluL

PDB Chain 4qluL

4qluM

PDB Chain 4qluM

4qluN

PDB Chain 4qluN

4qluO

PDB Chain 4qluO

4qluP

PDB Chain 4qluP

4qluQ

PDB Chain 4qluQ

4qluR

PDB Chain 4qluR

4qluS

PDB Chain 4qluS

4qluT

PDB Chain 4qluT

4qluU

PDB Chain 4qluU

4qluV

PDB Chain 4qluV

4qluW

PDB Chain 4qluW

4qluX

PDB Chain 4qluX

4qluY

PDB Chain 4qluY

4qluZ

PDB Chain 4qluZ

4qlua00

CATH Domain 4qlua00

4qluA00

CATH Domain 4qluA00

4qlub00

CATH Domain 4qlub00

4qluB00

CATH Domain 4qluB00

4qluC00

CATH Domain 4qluC00

4qluD00

CATH Domain 4qluD00

4qluE00

CATH Domain 4qluE00

4qluF00

CATH Domain 4qluF00

4qluG00

CATH Domain 4qluG00

4qluH00

CATH Domain 4qluH00

4qluI00

CATH Domain 4qluI00

4qluJ00

CATH Domain 4qluJ00

4qluK00

CATH Domain 4qluK00

4qluL00

CATH Domain 4qluL00

4qluM00

CATH Domain 4qluM00

4qluN00

CATH Domain 4qluN00

4qluO00

CATH Domain 4qluO00

4qluP00

CATH Domain 4qluP00

4qluQ00

CATH Domain 4qluQ00

4qluR00

CATH Domain 4qluR00

4qluS00

CATH Domain 4qluS00

4qluT00

CATH Domain 4qluT00

4qluU00

CATH Domain 4qluU00

4qluV00

CATH Domain 4qluV00

4qluW00

CATH Domain 4qluW00

4qluX00

CATH Domain 4qluX00

4qluY00

CATH Domain 4qluY00

4qluZ00

CATH Domain 4qluZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	11 Aug, 2014	Chopped
A	11 Aug, 2014	Chopped
b	11 Aug, 2014	Chopped
B	11 Aug, 2014	Chopped
C	11 Aug, 2014	Chopped
D	11 Aug, 2014	Chopped
E	11 Aug, 2014	Chopped
F	11 Aug, 2014	Chopped
G	11 Aug, 2014	Chopped
H	11 Aug, 2014	Chopped
I	11 Aug, 2014	Chopped
J	11 Aug, 2014	Chopped
K	11 Aug, 2014	Chopped
L	11 Aug, 2014	Chopped
M	11 Aug, 2014	Chopped
N	11 Aug, 2014	Chopped
O	11 Aug, 2014	Chopped
P	11 Aug, 2014	Chopped
Q	11 Aug, 2014	Chopped
R	11 Aug, 2014	Chopped
S	11 Aug, 2014	Chopped
T	11 Aug, 2014	Chopped
U	11 Aug, 2014	Chopped
V	11 Aug, 2014	Chopped
W	11 Aug, 2014	Chopped
X	11 Aug, 2014	Chopped
Y	11 Aug, 2014	Chopped
Z	11 Aug, 2014	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4qlua00	20 Aug, 2014	3.60.20.10	Assigned
4qluA00	20 Aug, 2014	3.60.20.10	Assigned
4qlub00	20 Aug, 2014	3.60.20.10	Assigned
4qluB00	20 Aug, 2014	3.60.20.10	Assigned
4qluC00	20 Aug, 2014	3.60.20.10	Assigned
4qluD00	20 Aug, 2014	3.60.20.10	Assigned
4qluE00	20 Aug, 2014	3.60.20.10	Assigned
4qluF00	20 Aug, 2014	3.60.20.10	Assigned
4qluG00	20 Aug, 2014	3.60.20.10	Assigned
4qluH00	20 Aug, 2014	3.60.20.10	Assigned
4qluI00	20 Aug, 2014	3.60.20.10	Assigned
4qluJ00	20 Aug, 2014	3.60.20.10	Assigned
4qluK00	20 Aug, 2014	3.60.20.10	Assigned
4qluL00	20 Aug, 2014	3.60.20.10	Assigned
4qluM00	20 Aug, 2014	3.60.20.10	Assigned
4qluN00	20 Aug, 2014	3.60.20.10	Assigned
4qluO00	20 Aug, 2014	3.60.20.10	Assigned
4qluP00	20 Aug, 2014	3.60.20.10	Assigned
4qluQ00	20 Aug, 2014	3.60.20.10	Assigned
4qluR00	20 Aug, 2014	3.60.20.10	Assigned
4qluS00	20 Aug, 2014	3.60.20.10	Assigned
4qluT00	20 Aug, 2014	3.60.20.10	Assigned
4qluU00	20 Aug, 2014	3.60.20.10	Assigned
4qluV00	20 Aug, 2014	3.60.20.10	Assigned
4qluW00	20 Aug, 2014	3.60.20.10	Assigned
4qluX00	20 Aug, 2014	3.60.20.10	Assigned
4qluY00	20 Aug, 2014	3.60.20.10	Assigned
4qluZ00	20 Aug, 2014	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7