PDB 4qlt

PDB Links
Overview

PDB Information

PDB	4QLT
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes De Bruin, G., Huber, E.M., Xin, B.T., Van Rooden, E.J., Al-Ayed, K., Kim, K.B., Kisselev, A.F., Driessen, C., Van der Stelt, M., Van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2014-06-13
Resolution	2.800
CATH Insert Date	10 Aug, 2014

PDB Images (57)

4qlt

PDB 4qlt

4qlta

PDB Chain 4qlta

4qltA

PDB Chain 4qltA

4qltb

PDB Chain 4qltb

4qltB

PDB Chain 4qltB

4qltC

PDB Chain 4qltC

4qltD

PDB Chain 4qltD

4qltE

PDB Chain 4qltE

4qltF

PDB Chain 4qltF

4qltG

PDB Chain 4qltG

4qltH

PDB Chain 4qltH

4qltI

PDB Chain 4qltI

4qltJ

PDB Chain 4qltJ

4qltK

PDB Chain 4qltK

4qltL

PDB Chain 4qltL

4qltM

PDB Chain 4qltM

4qltN

PDB Chain 4qltN

4qltO

PDB Chain 4qltO

4qltP

PDB Chain 4qltP

4qltQ

PDB Chain 4qltQ

4qltR

PDB Chain 4qltR

4qltS

PDB Chain 4qltS

4qltT

PDB Chain 4qltT

4qltU

PDB Chain 4qltU

4qltV

PDB Chain 4qltV

4qltW

PDB Chain 4qltW

4qltX

PDB Chain 4qltX

4qltY

PDB Chain 4qltY

4qltZ

PDB Chain 4qltZ

4qlta00

CATH Domain 4qlta00

4qltA00

CATH Domain 4qltA00

4qltb00

CATH Domain 4qltb00

4qltB00

CATH Domain 4qltB00

4qltC00

CATH Domain 4qltC00

4qltD00

CATH Domain 4qltD00

4qltE00

CATH Domain 4qltE00

4qltF00

CATH Domain 4qltF00

4qltG00

CATH Domain 4qltG00

4qltH00

CATH Domain 4qltH00

4qltI00

CATH Domain 4qltI00

4qltJ00

CATH Domain 4qltJ00

4qltK00

CATH Domain 4qltK00

4qltL00

CATH Domain 4qltL00

4qltM00

CATH Domain 4qltM00

4qltN00

CATH Domain 4qltN00

4qltO00

CATH Domain 4qltO00

4qltP00

CATH Domain 4qltP00

4qltQ00

CATH Domain 4qltQ00

4qltR00

CATH Domain 4qltR00

4qltS00

CATH Domain 4qltS00

4qltT00

CATH Domain 4qltT00

4qltU00

CATH Domain 4qltU00

4qltV00

CATH Domain 4qltV00

4qltW00

CATH Domain 4qltW00

4qltX00

CATH Domain 4qltX00

4qltY00

CATH Domain 4qltY00

4qltZ00

CATH Domain 4qltZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	11 Aug, 2014	Chopped
A	11 Aug, 2014	Chopped
b	11 Aug, 2014	Chopped
B	11 Aug, 2014	Chopped
C	11 Aug, 2014	Chopped
D	11 Aug, 2014	Chopped
E	11 Aug, 2014	Chopped
F	11 Aug, 2014	Chopped
G	11 Aug, 2014	Chopped
H	11 Aug, 2014	Chopped
I	11 Aug, 2014	Chopped
J	11 Aug, 2014	Chopped
K	11 Aug, 2014	Chopped
L	11 Aug, 2014	Chopped
M	11 Aug, 2014	Chopped
N	11 Aug, 2014	Chopped
O	11 Aug, 2014	Chopped
P	11 Aug, 2014	Chopped
Q	11 Aug, 2014	Chopped
R	11 Aug, 2014	Chopped
S	11 Aug, 2014	Chopped
T	11 Aug, 2014	Chopped
U	11 Aug, 2014	Chopped
V	11 Aug, 2014	Chopped
W	11 Aug, 2014	Chopped
X	11 Aug, 2014	Chopped
Y	11 Aug, 2014	Chopped
Z	11 Aug, 2014	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4qlta00	20 Aug, 2014	3.60.20.10	Assigned
4qltA00	20 Aug, 2014	3.60.20.10	Assigned
4qltb00	20 Aug, 2014	3.60.20.10	Assigned
4qltB00	20 Aug, 2014	3.60.20.10	Assigned
4qltC00	20 Aug, 2014	3.60.20.10	Assigned
4qltD00	20 Aug, 2014	3.60.20.10	Assigned
4qltE00	20 Aug, 2014	3.60.20.10	Assigned
4qltF00	20 Aug, 2014	3.60.20.10	Assigned
4qltG00	20 Aug, 2014	3.60.20.10	Assigned
4qltH00	20 Aug, 2014	3.60.20.10	Assigned
4qltI00	20 Aug, 2014	3.60.20.10	Assigned
4qltJ00	20 Aug, 2014	3.60.20.10	Assigned
4qltK00	20 Aug, 2014	3.60.20.10	Assigned
4qltL00	20 Aug, 2014	3.60.20.10	Assigned
4qltM00	20 Aug, 2014	3.60.20.10	Assigned
4qltN00	20 Aug, 2014	3.60.20.10	Assigned
4qltO00	20 Aug, 2014	3.60.20.10	Assigned
4qltP00	20 Aug, 2014	3.60.20.10	Assigned
4qltQ00	20 Aug, 2014	3.60.20.10	Assigned
4qltR00	20 Aug, 2014	3.60.20.10	Assigned
4qltS00	20 Aug, 2014	3.60.20.10	Assigned
4qltT00	20 Aug, 2014	3.60.20.10	Assigned
4qltU00	20 Aug, 2014	3.60.20.10	Assigned
4qltV00	20 Aug, 2014	3.60.20.10	Assigned
4qltW00	20 Aug, 2014	3.60.20.10	Assigned
4qltX00	20 Aug, 2014	3.60.20.10	Assigned
4qltY00	20 Aug, 2014	3.60.20.10	Assigned
4qltZ00	20 Aug, 2014	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1