PDB 4pyv

PDB Information

PDB4PYV
MethodX-RAY DIFFRACTION
Host OrganismCricetulus griseus
Gene SourceHomo sapiens
Primary Citation
Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors.
Ehara, T., Irie, O., Kosaka, T., Kanazawa, T., Breitenstein, W., Grosche, P., Ostermann, N., Suzuki, M., Kawakami, S., Konishi, K., Hitomi, Y., Toyao, A., Gunji, H., Cumin, F., Schiering, N., Wagner, T., Rigel, D.F., Webb, R.L., Maibaum, J., Yokokawa, F.
ACS Med Chem Lett
HeaderHydrolase/Hydrolase Inhibitor
Released2014-03-28
Resolution2.650
CATH Insert Date19 Oct, 2014

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 20 Oct, 2014 Chopped
B 20 Oct, 2014 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4pyvA01 21 Oct, 2014 2.40.70.10 Assigned
4pyvA02 21 Oct, 2014 2.40.70.10 Assigned
4pyvB01 21 Oct, 2014 2.40.70.10 Assigned
4pyvB02 21 Oct, 2014 2.40.70.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P00797 RENI_HUMAN Homo sapiens Renin
P00797 RENI_HUMAN Homo sapiens Renin