PDB 4p59

PDB Information

PDB4P59
MethodX-RAY DIFFRACTION
Host OrganismHomo sapiens
Gene SourceHomo sapiens
Primary Citation
An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin.
Garner, A.P., Bialucha, C.U., Sprague, E.R., Garrett, J.T., Sheng, Q., Li, S., Sineshchekova, O., Saxena, P., Sutton, C.R., Chen, D., Chen, Y., Wang, H., Liang, J., Das, R., Mosher, R., Gu, J., Huang, A., Haubst, N., Zehetmeier, C., Haberl, M., Elis, W., Kunz, C., Heidt, A.B., Herlihy, K., Murtie, J., Schuller, A., Arteaga, C.L., Sellers, W.R., Ettenberg, S.A.
Cancer Res.
HeaderSignaling Protein, Immune System
Released2014-03-15
Resolution3.400
CATH Insert Date20 Apr, 2014

PDB Images (12)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
A 21 Apr, 2014 Chopped
H 21 Apr, 2014 Chopped
L 21 Apr, 2014 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4p59A01 25 Apr, 2014 3.80.20.20 Assigned
4p59A02 25 Apr, 2014 2.10.220.10 Assigned
4p59A03 25 Apr, 2014 3.80.20.20 Assigned
4p59A04 25 Apr, 2014 2.10.220.10 Assigned
4p59H01 25 Apr, 2014 2.60.40.10 Assigned
4p59H02 25 Apr, 2014 2.60.40.10 Assigned
4p59L01 25 Apr, 2014 2.60.40.10 Assigned
4p59L02 25 Apr, 2014 2.60.40.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P21860 ERBB3_HUMAN Homo sapiens Receptor tyrosine-protein kinase erbB-3