PDB Information

PDB4NWL
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHepatitis C virus
Primary Citation
Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.
Scola, P.M., Wang, A.X., Good, A.C., Sun, L.Q., Combrink, K.D., Campbell, J.A., Chen, J., Tu, Y., Sin, N., Venables, B.L., Sit, S.Y., Chen, Y., Cocuzza, A., Bilder, D.M., D'Andrea, S., Zheng, B., Hewawasam, P., Ding, M., Thuring, J., Li, J., Hernandez, D., Yu, F., Falk, P., Zhai, G., Sheaffer, A.K., Chen, C., Lee, M.S., Barry, D., Knipe, J.O., Li, W., Han, Y.H., Jenkins, S., Gesenberg, C., Gao, Q., Sinz, M.W., Santone, K.S., Zvyaga, T., Rajamani, R., Klei, H.E., Colonno, R.J., Grasela, D.M., Hughes, E., Chien, C., Adams, S., Levesque, P.C., Li, D., Zhu, J., Meanwell, N.A., McPhee, F.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2013-12-06
Resolution2.200
CATH Insert Date30 Mar, 2014

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 31 Mar, 2014 Chopped
B 31 Mar, 2014 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4nwlA01 25 Apr, 2014 2.40.10.120 Assigned
4nwlA02 25 Apr, 2014 2.40.10.10 Assigned
4nwlB01 25 Apr, 2014 2.40.10.120 Assigned
4nwlB02 25 Apr, 2014 2.40.10.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
A8DG50 A8DG50_9HEPC Hepatitis C virus subtype 1a Genome polyprotein
A8DG50 A8DG50_9HEPC Hepatitis C virus subtype 1a Genome polyprotein
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