PDB 4nce

PDB Information

PDB4NCE
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceInfluenza A virus
Primary Citation
Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2.
Clark, M.P., Ledeboer, M.W., Davies, I., Byrn, R.A., Jones, S.M., Perola, E., Tsai, A., Jacobs, M., Nti-Addae, K., Bandarage, U.K., Boyd, M.J., Bethiel, R.S., Court, J.J., Deng, H., Duffy, J.P., Dorsch, W.A., Farmer, L.J., Gao, H., Gu, W., Jackson, K., Jacobs, D.H., Kennedy, J.M., Ledford, B., Liang, J., Maltais, F., Murcko, M., Wang, T., Wannamaker, M.W., Bennett, H.B., Leeman, J.R., McNeil, C., Taylor, W.P., Memmott, C., Jiang, M., Rijnbrand, R., Bral, C., Germann, U., Nezami, A., Zhang, Y., Salituro, F.G., Bennani, Y.L., Charifson, P.S.
J.Med.Chem.
HeaderTranscription/Transcription Inhibitor
Released2013-10-24
Resolution2.300
CATH Insert Date10 Aug, 2014

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 11 Aug, 2014 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
4nceA00 19 Aug, 2014 Holding pen

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P31345 PB2_I75A3 Influenza A virus (A/Victoria/3/1975(H3N2)) Polymerase basic protein 2