PDB 4lxm

PDB Links
Overview

PDB Information

PDB	4LXM
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides. Rueeger, H., Lueoend, R., Machauer, R., Veenstra, S.J., Jacobson, L.H., Staufenbiel, M., Desrayaud, S., Rondeau, J.M., Mobitz, H., Neumann, U. Bioorg.Med.Chem.Lett.
Header	Hydrolase/Hydrolase Inhibitor
Released	2013-07-30
Resolution	2.300
CATH Insert Date	15 Sep, 2013

PDB Images (10)

Image of CATH 4lxm

4lxm

PDB 4lxm

Image of CATH 4lxmA

4lxmA

PDB Chain 4lxmA

Image of CATH 4lxmB

4lxmB

PDB Chain 4lxmB

Image of CATH 4lxmC

4lxmC

PDB Chain 4lxmC

Image of CATH 4lxmA01

4lxmA01

CATH Domain 4lxmA01

Image of CATH 4lxmA02

4lxmA02

CATH Domain 4lxmA02

Image of CATH 4lxmB01

4lxmB01

CATH Domain 4lxmB01

Image of CATH 4lxmB02

4lxmB02

CATH Domain 4lxmB02

Image of CATH 4lxmC01

4lxmC01

CATH Domain 4lxmC01

Image of CATH 4lxmC02

4lxmC02

CATH Domain 4lxmC02

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	16 Sep, 2013	Chopped
B	16 Sep, 2013	Chopped
C	16 Sep, 2013	Chopped

CATH Domains (6)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4lxmA01	01 Nov, 2013	2.40.70.10	Assigned
4lxmA02	01 Nov, 2013	2.40.70.10	Assigned
4lxmB01	01 Nov, 2013	2.40.70.10	Assigned
4lxmB02	01 Nov, 2013	2.40.70.10	Assigned
4lxmC01	01 Nov, 2013	2.40.70.10	Assigned
4lxmC02	01 Nov, 2013	2.40.70.10	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1