PDB 4lxa

PDB Links
Overview

PDB Information

PDB	4LXA
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides. Rueeger, H., Lueoend, R., Machauer, R., Veenstra, S.J., Jacobson, L.H., Staufenbiel, M., Desrayaud, S., Rondeau, J.M., Mobitz, H., Neumann, U. Bioorg.Med.Chem.Lett.
Header	Hydrolase/Hydrolase Inhibitor
Released	2013-07-29
Resolution	1.950
CATH Insert Date	15 Sep, 2013

PDB Images (10)

Image of CATH 4lxa

4lxa

PDB 4lxa

Image of CATH 4lxaA

4lxaA

PDB Chain 4lxaA

Image of CATH 4lxaB

4lxaB

PDB Chain 4lxaB

Image of CATH 4lxaC

4lxaC

PDB Chain 4lxaC

Image of CATH 4lxaA01

4lxaA01

CATH Domain 4lxaA01

Image of CATH 4lxaA02

4lxaA02

CATH Domain 4lxaA02

Image of CATH 4lxaB01

4lxaB01

CATH Domain 4lxaB01

Image of CATH 4lxaB02

4lxaB02

CATH Domain 4lxaB02

Image of CATH 4lxaC01

4lxaC01

CATH Domain 4lxaC01

Image of CATH 4lxaC02

4lxaC02

CATH Domain 4lxaC02

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	16 Sep, 2013	Chopped
B	16 Sep, 2013	Chopped
C	16 Sep, 2013	Chopped

CATH Domains (6)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4lxaA01	01 Nov, 2013	2.40.70.10	Assigned
4lxaA02	01 Nov, 2013	2.40.70.10	Assigned
4lxaB01	01 Nov, 2013	2.40.70.10	Assigned
4lxaB02	01 Nov, 2013	2.40.70.10	Assigned
4lxaC01	01 Nov, 2013	2.40.70.10	Assigned
4lxaC02	01 Nov, 2013	2.40.70.10	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1