PDB 4lwu

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Overview

PDB Information

PDB	4LWU
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Xenopus laevis
Primary Citation	Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy. Zhang, Z., Ding, Q., Liu, J.J., Zhang, J., Jiang, N., Chu, X.J., Bartkovitz, D., Luk, K.C., Janson, C., Tovar, C., Filipovic, Z.M., Higgins, B., Glenn, K., Packman, K., Vassilev, L.T., Graves, B. Bioorg.Med.Chem.
Header	Ligase/Ligase Inhibitor
Released	2013-07-28
Resolution	1.140
CATH Insert Date	27 Jul, 2014

PDB Images (3)

Image of CATH 4lwu

4lwu

PDB 4lwu

Image of CATH 4lwuA

4lwuA

PDB Chain 4lwuA

Image of CATH 4lwuA00

4lwuA00

CATH Domain 4lwuA00

PDB Prints

PDB Chains (1)

Chain ID	Date inserted into CATH	CATH Status
A	28 Jul, 2014	Chopped

CATH Domains (1)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4lwuA00	03 Aug, 2014	1.10.245.10	Assigned

UniProtKB Entries (1)

Accession	Gene ID	Taxon	Description
P56273	MDM2_XENLA	Xenopus laevis	E3 ubiquitin-protein ligase Mdm2