PDB 4kio

PDB Information

PDB4KIO
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket.
Harling, J.D., Deakin, A.M., Campos, S., Grimley, R., Chaudry, L., Nye, C., Polyakova, O., Bessant, C.M., Barton, N., Somers, D., Barrett, J., Graves, R.H., Hanns, L., Kerr, W.J., Solari, R.
J.Biol.Chem.
HeaderTransferase/Transferase Inhibitor
Released2013-05-02
Resolution2.180
CATH Insert Date01 Sep, 2013

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 02 Sep, 2013 Chopped
B 02 Sep, 2013 Chopped
C 02 Sep, 2013 Chopped
D 02 Sep, 2013 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4kioA01 10 Sep, 2013 3.30.200.20 Assigned
4kioA02 10 Sep, 2013 1.10.510.10 Assigned
4kioB01 10 Sep, 2013 3.30.200.20 Assigned
4kioB02 10 Sep, 2013 1.10.510.10 Assigned
4kioC01 10 Sep, 2013 3.30.200.20 Assigned
4kioC02 10 Sep, 2013 1.10.510.10 Assigned
4kioD01 10 Sep, 2013 3.30.200.20 Assigned
4kioD02 10 Sep, 2013 1.10.510.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q08881 ITK_HUMAN Homo sapiens Tyrosine-protein kinase ITK/TSK
Q08881 ITK_HUMAN Homo sapiens Tyrosine-protein kinase ITK/TSK
Q08881 ITK_HUMAN Homo sapiens Tyrosine-protein kinase ITK/TSK
Q08881 ITK_HUMAN Homo sapiens Tyrosine-protein kinase ITK/TSK