PDB 4ke0

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Overview

PDB Information

PDB	4KE0
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Hydroxyethylamine-based inhibitors of BACE1: P1-P3 macrocyclization can improve potency, selectivity, and cell activity. Pennington, L.D., Whittington, D.A., Bartberger, M.D., Jordan, S.R., Monenschein, H., Nguyen, T.T., Yang, B.H., Xue, Q.M., Vounatsos, F., Wahl, R.C., Chen, K., Wood, S., Citron, M., Patel, V.F., Hitchcock, S.A., Zhong, W. Bioorg.Med.Chem.Lett.
Header	Hydrolase/Hydrolase Inhibitor
Released	2013-04-25
Resolution	2.300
CATH Insert Date	04 Aug, 2013

PDB Images (10)

Image of CATH 4ke0

4ke0

PDB 4ke0

Image of CATH 4ke0A

4ke0A

PDB Chain 4ke0A

Image of CATH 4ke0B

4ke0B

PDB Chain 4ke0B

Image of CATH 4ke0C

4ke0C

PDB Chain 4ke0C

Image of CATH 4ke0A01

4ke0A01

CATH Domain 4ke0A01

Image of CATH 4ke0A02

4ke0A02

CATH Domain 4ke0A02

Image of CATH 4ke0B01

4ke0B01

CATH Domain 4ke0B01

Image of CATH 4ke0B02

4ke0B02

CATH Domain 4ke0B02

Image of CATH 4ke0C01

4ke0C01

CATH Domain 4ke0C01

Image of CATH 4ke0C02

4ke0C02

CATH Domain 4ke0C02

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	05 Aug, 2013	Chopped
B	05 Aug, 2013	Chopped
C	05 Aug, 2013	Chopped

CATH Domains (6)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4ke0A01	14 Aug, 2013	2.40.70.10	Assigned
4ke0A02	14 Aug, 2013	2.40.70.10	Assigned
4ke0B01	14 Aug, 2013	2.40.70.10	Assigned
4ke0B02	14 Aug, 2013	2.40.70.10	Assigned
4ke0C01	14 Aug, 2013	2.40.70.10	Assigned
4ke0C02	14 Aug, 2013	2.40.70.10	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1