PDB 4k8s

PDB Links
Overview

PDB Information

PDB	4K8S
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Hydroxyethylamine-based inhibitors of BACE1: P1-P3 macrocyclization can improve potency, selectivity, and cell activity. Pennington, L.D., Whittington, D.A., Bartberger, M.D., Jordan, S.R., Monenschein, H., Nguyen, T.T., Yang, B.H., Xue, Q.M., Vounatsos, F., Wahl, R.C., Chen, K., Wood, S., Citron, M., Patel, V.F., Hitchcock, S.A., Zhong, W. Bioorg.Med.Chem.Lett.
Header	Hydrolase/Hydrolase Inhibitor
Released	2013-04-18
Resolution	2.390
CATH Insert Date	04 Aug, 2013

PDB Images (10)

Image of CATH 4k8s

4k8s

PDB 4k8s

Image of CATH 4k8sA

4k8sA

PDB Chain 4k8sA

Image of CATH 4k8sB

4k8sB

PDB Chain 4k8sB

Image of CATH 4k8sC

4k8sC

PDB Chain 4k8sC

Image of CATH 4k8sA01

4k8sA01

CATH Domain 4k8sA01

Image of CATH 4k8sA02

4k8sA02

CATH Domain 4k8sA02

Image of CATH 4k8sB01

4k8sB01

CATH Domain 4k8sB01

Image of CATH 4k8sB02

4k8sB02

CATH Domain 4k8sB02

Image of CATH 4k8sC01

4k8sC01

CATH Domain 4k8sC01

Image of CATH 4k8sC02

4k8sC02

CATH Domain 4k8sC02

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	05 Aug, 2013	Chopped
B	05 Aug, 2013	Chopped
C	05 Aug, 2013	Chopped

CATH Domains (6)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4k8sA01	14 Aug, 2013	2.40.70.10	Assigned
4k8sA02	14 Aug, 2013	2.40.70.10	Assigned
4k8sB01	14 Aug, 2013	2.40.70.10	Assigned
4k8sB02	14 Aug, 2013	2.40.70.10	Assigned
4k8sC01	14 Aug, 2013	2.40.70.10	Assigned
4k8sC02	14 Aug, 2013	2.40.70.10	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1