PDB Information

PDB4JLG
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
Barsyte-Lovejoy, D., Li, F., Oudhoff, M.J., Tatlock, J.H., Dong, A., Zeng, H., Wu, H., Freeman, S.A., Schapira, M., Senisterra, G.A., Kuznetsova, E., Marcellus, R., Allali-Hassani, A., Kennedy, S., Lambert, J.P., Couzens, A.L., Aman, A., Gingras, A.C., Al-Awar, R., Fish, P.V., Gerstenberger, B.S., Roberts, L., Benn, C.L., Grimley, R.L., Braam, M.J., Rossi, F.M., Sudol, M., Brown, P.J., Bunnage, M.E., Owen, D.R., Zaph, C., Vedadi, M., Arrowsmith, C.H.
Proc.Natl.Acad.Sci.USA
HeaderTransferase/Transferase Inhibitor
Released2013-03-12
Resolution1.900
CATH Insert Date07 Jul, 2013

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 08 Jul, 2013 Chopped
B 08 Jul, 2013 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4jlgA01 09 Aug, 2013 2.20.110.10 Assigned
4jlgA02 09 Aug, 2013 2.170.270.10 Assigned
4jlgB01 09 Aug, 2013 2.20.110.10 Assigned
4jlgB02 09 Aug, 2013 2.170.270.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q8WTS6 SETD7_HUMAN Homo sapiens Histone-lysine N-methyltransferase SETD7
Q8WTS6 SETD7_HUMAN Homo sapiens Histone-lysine N-methyltransferase SETD7