Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2.
Zak, M., Hurley, C.A., Ward, S.I., Bergeron, P., Barrett, K., Balazs, M., Blair, W.S., Bull, R., Chakravarty, P., Chang, C., Crackett, P., Deshmukh, G., Devoss, J., Dragovich, P.S., Eigenbrot, C., Ellwood, C., Gaines, S., Ghilardi, N., Gibbons, P., Gradl, S., Gribling, P., Hamman, C., Harstad, E., Hewitt, P., Johnson, A., Johnson, T., Kenny, J.R., Koehler, M.F., Bir Kohli, P., Labadie, S., Lee, W.P., Liao, J., Liimatta, M., Mendonca, R., Narukulla, R., Pulk, R., Reeve, A., Savage, S., Shia, S., Steffek, M., Ubhayakar, S., van Abbema, A., Aliagas, I., Avitabile-Woo, B., Xiao, Y., Yang, J., Kulagowski, J.J.
J.Med.Chem.