PDB 4i11

PDB Information

PDB4I11
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Bowers, S., Xu, Y.Z., Yuan, S., Probst, G.D., Hom, R.K., Chan, W., Konradi, A.W., Sham, H.L., Zhu, Y.L., Beroza, P., Pan, H., Brecht, E., Yao, N., Lougheed, J., Tam, D., Ren, Z., Ruslim, L., Bova, M.P., Artis, D.R.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2012-11-19
Resolution1.890
CATH Insert Date28 Mar, 2013

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 28 Mar, 2013 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4i11A01 10 Apr, 2013 2.40.70.10 Assigned
4i11A02 10 Apr, 2013 2.40.70.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1