PDB 4hx5

PDB Links
Overview

PDB Information

PDB	4HX5
Method	X-RAY DIFFRACTION
Host Organism	ESCHERICHIA COLI
Gene Source	Homo sapiens
Primary Citation	Discovery of SAR184841, a potent and long-lasting inhibitor of 11beta-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D Venier, O., Pascal, C., Braun, A., Namane, C., Mougenot, P., Crespin, O., Pacquet, F., Mougenot, C., Monseau, C., Onofri, B., Dadji-Faihun, R., Leger, C., Ben-Hassine, M., Van-Pham, T., Ragot, J.L., Philippo, C., Farjot, G., Noah, L., Maniani, K., Boutarfa, A., Nicolai, E., Guillot, E., Pruniaux, M.P., Gussregen, S., Engel, C., Coutant, A.L., de Miguel, B., Castro, A. Bioorg.Med.Chem.Lett.
Header	Oxidoreductase/Oxidoreductase Inhibitor
Released	2012-11-09
Resolution	2.190
CATH Insert Date	07 Jul, 2013

PDB Images (9)

Image of CATH 4hx5

4hx5

PDB 4hx5

Image of CATH 4hx5A

4hx5A

PDB Chain 4hx5A

Image of CATH 4hx5B

4hx5B

PDB Chain 4hx5B

Image of CATH 4hx5C

4hx5C

PDB Chain 4hx5C

Image of CATH 4hx5D

4hx5D

PDB Chain 4hx5D

Image of CATH 4hx5A00

4hx5A00

CATH Domain 4hx5A00

Image of CATH 4hx5B00

4hx5B00

CATH Domain 4hx5B00

Image of CATH 4hx5C00

4hx5C00

CATH Domain 4hx5C00

Image of CATH 4hx5D00

4hx5D00

CATH Domain 4hx5D00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	08 Jul, 2013	Chopped
B	08 Jul, 2013	Chopped
C	08 Jul, 2013	Chopped
D	08 Jul, 2013	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4hx5A00	09 Aug, 2013	3.40.50.720	Assigned
4hx5B00	09 Aug, 2013	3.40.50.720	Assigned
4hx5C00	09 Aug, 2013	3.40.50.720	Assigned
4hx5D00	09 Aug, 2013	3.40.50.720	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
P28845	DHI1_HUMAN	Homo sapiens	Corticosteroid 11-beta-dehydrogenase isozyme 1
P28845	DHI1_HUMAN	Homo sapiens	Corticosteroid 11-beta-dehydrogenase isozyme 1
P28845	DHI1_HUMAN	Homo sapiens	Corticosteroid 11-beta-dehydrogenase isozyme 1
P28845	DHI1_HUMAN	Homo sapiens	Corticosteroid 11-beta-dehydrogenase isozyme 1