PDB 4gk7

PDB Links
Overview

PDB Information

PDB	4GK7
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cells. Archer, C.R., Groll, M., Stein, M.L., Schellenberg, B., Clerc, J., Kaiser, M., Kondratyuk, T.P., Pezzuto, J.M., Dudler, R., Bachmann, A.S. Biochemistry
Header	Hydrolase/Hydrolase Inhibitor
Released	2012-08-10
Resolution	2.800
CATH Insert Date	04 Nov, 2012

PDB Images (63)

4gk7

PDB 4gk7

4gk71

PDB Chain 4gk71

4gk72

PDB Chain 4gk72

4gk73

PDB Chain 4gk73

4gk74

PDB Chain 4gk74

4gk75

PDB Chain 4gk75

4gk76

PDB Chain 4gk76

4gk7a

PDB Chain 4gk7a

4gk7A

PDB Chain 4gk7A

4gk7b

PDB Chain 4gk7b

4gk7B

PDB Chain 4gk7B

4gk7C

PDB Chain 4gk7C

4gk7D

PDB Chain 4gk7D

4gk7E

PDB Chain 4gk7E

4gk7F

PDB Chain 4gk7F

4gk7G

PDB Chain 4gk7G

4gk7H

PDB Chain 4gk7H

4gk7I

PDB Chain 4gk7I

4gk7J

PDB Chain 4gk7J

4gk7K

PDB Chain 4gk7K

4gk7L

PDB Chain 4gk7L

4gk7M

PDB Chain 4gk7M

4gk7N

PDB Chain 4gk7N

4gk7O

PDB Chain 4gk7O

4gk7P

PDB Chain 4gk7P

4gk7Q

PDB Chain 4gk7Q

4gk7R

PDB Chain 4gk7R

4gk7S

PDB Chain 4gk7S

4gk7T

PDB Chain 4gk7T

4gk7U

PDB Chain 4gk7U

4gk7V

PDB Chain 4gk7V

4gk7W

PDB Chain 4gk7W

4gk7X

PDB Chain 4gk7X

4gk7Y

PDB Chain 4gk7Y

4gk7Z

PDB Chain 4gk7Z

4gk7a00

CATH Domain 4gk7a00

4gk7A00

CATH Domain 4gk7A00

4gk7b00

CATH Domain 4gk7b00

4gk7B00

CATH Domain 4gk7B00

4gk7C00

CATH Domain 4gk7C00

4gk7D00

CATH Domain 4gk7D00

4gk7E00

CATH Domain 4gk7E00

4gk7F00

CATH Domain 4gk7F00

4gk7G00

CATH Domain 4gk7G00

4gk7H00

CATH Domain 4gk7H00

4gk7I00

CATH Domain 4gk7I00

4gk7J00

CATH Domain 4gk7J00

4gk7K00

CATH Domain 4gk7K00

4gk7L00

CATH Domain 4gk7L00

4gk7M00

CATH Domain 4gk7M00

4gk7N00

CATH Domain 4gk7N00

4gk7O00

CATH Domain 4gk7O00

4gk7P00

CATH Domain 4gk7P00

4gk7Q00

CATH Domain 4gk7Q00

4gk7R00

CATH Domain 4gk7R00

4gk7S00

CATH Domain 4gk7S00

4gk7T00

CATH Domain 4gk7T00

4gk7U00

CATH Domain 4gk7U00

4gk7V00

CATH Domain 4gk7V00

4gk7W00

CATH Domain 4gk7W00

4gk7X00

CATH Domain 4gk7X00

4gk7Y00

CATH Domain 4gk7Y00

4gk7Z00

CATH Domain 4gk7Z00

PDB Prints

PDB Chains (34)

Chain ID	Date inserted into CATH	CATH Status
1	05 Nov, 2012	Rejected
2	05 Nov, 2012	Rejected
3	05 Nov, 2012	Rejected
4	05 Nov, 2012	Rejected
5	05 Nov, 2012	Rejected
6	05 Nov, 2012	Rejected
a	05 Nov, 2012	Chopped
A	05 Nov, 2012	Chopped
b	05 Nov, 2012	Chopped
B	05 Nov, 2012	Chopped
C	05 Nov, 2012	Chopped
D	05 Nov, 2012	Chopped
E	05 Nov, 2012	Chopped
F	05 Nov, 2012	Chopped
G	05 Nov, 2012	Chopped
H	05 Nov, 2012	Chopped
I	05 Nov, 2012	Chopped
J	05 Nov, 2012	Chopped
K	05 Nov, 2012	Chopped
L	05 Nov, 2012	Chopped
M	05 Nov, 2012	Chopped
N	05 Nov, 2012	Chopped
O	05 Nov, 2012	Chopped
P	05 Nov, 2012	Chopped
Q	05 Nov, 2012	Chopped
R	05 Nov, 2012	Chopped
S	05 Nov, 2012	Chopped
T	05 Nov, 2012	Chopped
U	05 Nov, 2012	Chopped
V	05 Nov, 2012	Chopped
W	05 Nov, 2012	Chopped
X	05 Nov, 2012	Chopped
Y	05 Nov, 2012	Chopped
Z	05 Nov, 2012	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4gk7a00	10 Nov, 2012	3.60.20.10	Assigned
4gk7A00	05 Feb, 2013	3.60.20.10	Assigned
4gk7b00	10 Nov, 2012	3.60.20.10	Assigned
4gk7B00	05 Feb, 2013	3.60.20.10	Assigned
4gk7C00	05 Feb, 2013	3.60.20.10	Assigned
4gk7D00	08 Feb, 2013	3.60.20.10	Assigned
4gk7E00	10 Nov, 2012	3.60.20.10	Assigned
4gk7F00	10 Nov, 2012	3.60.20.10	Assigned
4gk7G00	10 Nov, 2012	3.60.20.10	Assigned
4gk7H00	10 Nov, 2012	3.60.20.10	Assigned
4gk7I00	10 Nov, 2012	3.60.20.10	Assigned
4gk7J00	10 Nov, 2012	3.60.20.10	Assigned
4gk7K00	10 Nov, 2012	3.60.20.10	Assigned
4gk7L00	10 Nov, 2012	3.60.20.10	Assigned
4gk7M00	10 Nov, 2012	3.60.20.10	Assigned
4gk7N00	10 Nov, 2012	3.60.20.10	Assigned
4gk7O00	05 Feb, 2013	3.60.20.10	Assigned
4gk7P00	05 Feb, 2013	3.60.20.10	Assigned
4gk7Q00	05 Feb, 2013	3.60.20.10	Assigned
4gk7R00	08 Feb, 2013	3.60.20.10	Assigned
4gk7S00	10 Nov, 2012	3.60.20.10	Assigned
4gk7T00	10 Nov, 2012	3.60.20.10	Assigned
4gk7U00	10 Nov, 2012	3.60.20.10	Assigned
4gk7V00	10 Nov, 2012	3.60.20.10	Assigned
4gk7W00	10 Nov, 2012	3.60.20.10	Assigned
4gk7X00	10 Nov, 2012	3.60.20.10	Assigned
4gk7Y00	10 Nov, 2012	3.60.20.10	Assigned
4gk7Z00	10 Nov, 2012	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5