PDB 4flh

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Overview

PDB Information

PDB	4FLH
Method	X-RAY DIFFRACTION
Host Organism	Spodoptera frugiperda
Gene Source	Homo sapiens
Primary Citation	Selective Class I Phosphoinositide 3-Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511. Norman, M.H., Andrews, K.L., Bo, Y.Y., Booker, S.K., Caenepeel, S., Cee, V.J., D'Angelo, N.D., Freeman, D.J., Herberich, B.J., Hong, F.T., Jackson, C.L., Jiang, J., Lanman, B.A., Liu, L., McCarter, J.D., Mullady, E.L., Nishimura, N., Pettus, L.H., Reed, A.B., Miguel, T.S., Smith, A.L., Stec, M.M., Tadesse, S., Tasker, A., Aidasani, D., Zhu, X., Subramanian, R., Tamayo, N.A., Wang, L., Whittington, D.A., Wu, B., Wu, T., Wurz, R.P., Yang, K., Zalameda, L., Zhang, N., Hughes, P.E. J.Med.Chem.
Header	Transferase/Inhibitor
Released	2012-06-14
Resolution	2.600
CATH Insert Date	04 Nov, 2012

PDB Images (7)

Image of CATH 4flh

4flh

PDB 4flh

Image of CATH 4flhA

4flhA

PDB Chain 4flhA

Image of CATH 4flhA01

4flhA01

CATH Domain 4flhA01

Image of CATH 4flhA02

4flhA02

CATH Domain 4flhA02

Image of CATH 4flhA03

4flhA03

CATH Domain 4flhA03

Image of CATH 4flhA04

4flhA04

CATH Domain 4flhA04

Image of CATH 4flhA05

4flhA05

CATH Domain 4flhA05

PDB Prints

PDB Chains (1)

Chain ID	Date inserted into CATH	CATH Status
A	05 Nov, 2012	Chopped

CATH Domains (5)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4flhA01	10 Nov, 2012	3.10.20.90	Assigned
4flhA02	10 Nov, 2012	2.60.40.150	Assigned
4flhA03	10 Nov, 2012	1.25.40.70	Assigned
4flhA04	10 Nov, 2012	3.30.1010.10	Assigned
4flhA05	10 Nov, 2012	1.10.1070.11	Assigned

UniProtKB Entries (1)

Accession	Gene ID	Taxon	Description
P48736	PK3CG_HUMAN	Homo sapiens	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform