PDB 4fk6

PDB Information

PDB4FK6
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2.
Labadie, S., Dragovich, P.S., Barrett, K., Blair, W.S., Bergeron, P., Chang, C., Deshmukh, G., Eigenbrot, C., Ghilardi, N., Gibbons, P., Hurley, C.A., Johnson, A., Kenny, J.R., Kohli, P.B., Kulagowski, J.J., Liimatta, M., Lupardus, P.J., Mendonca, R., Murray, J.M., Pulk, R., Shia, S., Steffek, M., Ubhayakar, S., Ultsch, M., van Abbema, A., Ward, S., Zak, M.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2012-06-12
Resolution2.200
CATH Insert Date11 Nov, 2012

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 12 Nov, 2012 Chopped
B 12 Nov, 2012 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4fk6A01 19 Nov, 2012 3.30.200.20 Assigned
4fk6A02 19 Nov, 2012 1.10.510.10 Assigned
4fk6B01 19 Nov, 2012 3.30.200.20 Assigned
4fk6B02 19 Nov, 2012 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P23458 JAK1_HUMAN Homo sapiens Tyrosine-protein kinase JAK1
P23458 JAK1_HUMAN Homo sapiens Tyrosine-protein kinase JAK1