PDB 4ehz

PDB Information

PDB4EHZ
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2.
Zak, M., Mendonca, R., Balazs, M., Barrett, K., Bergeron, P., Blair, W.S., Chang, C., Deshmukh, G., Devoss, J., Dragovich, P.S., Eigenbrot, C., Ghilardi, N., Gibbons, P., Gradl, S., Hamman, C., Hanan, E.J., Harstad, E., Hewitt, P.R., Hurley, C.A., Jin, T., Johnson, A., Johnson, T., Kenny, J.R., Koehler, M.F., Bir Kohli, P., Kulagowski, J.J., Labadie, S., Liao, J., Liimatta, M., Lin, Z., Lupardus, P.J., Maxey, R.J., Murray, J.M., Pulk, R., Rodriguez, M., Savage, S., Shia, S., Steffek, M., Ubhayakar, S., Ultsch, M., van Abbema, A., Ward, S.I., Xiao, L., Xiao, Y.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2012-04-04
Resolution2.170
CATH Insert Date04 Nov, 2012

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 05 Nov, 2012 Chopped
B 05 Nov, 2012 Chopped
C 05 Nov, 2012 Chopped
D 05 Nov, 2012 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4ehzA01 10 Nov, 2012 3.30.200.20 Assigned
4ehzA02 10 Nov, 2012 1.10.510.10 Assigned
4ehzB01 10 Nov, 2012 3.30.200.20 Assigned
4ehzB02 10 Nov, 2012 1.10.510.10 Assigned
4ehzC01 10 Nov, 2012 3.30.200.20 Assigned
4ehzC02 10 Nov, 2012 1.10.510.10 Assigned
4ehzD01 10 Nov, 2012 3.30.200.20 Assigned
4ehzD02 10 Nov, 2012 1.10.510.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P23458 JAK1_HUMAN Homo sapiens Tyrosine-protein kinase JAK1
P23458 JAK1_HUMAN Homo sapiens Tyrosine-protein kinase JAK1
P23458 JAK1_HUMAN Homo sapiens Tyrosine-protein kinase JAK1
P23458 JAK1_HUMAN Homo sapiens Tyrosine-protein kinase JAK1