PDB 4e4x

PDB Links
Overview

PDB Information

PDB	4E4X
Method	X-RAY DIFFRACTION
Host Organism	Trichoplusia ni
Gene Source	Homo sapiens
Primary Citation	The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-Raf(V600E) kinase. Ren, L., Ahrendt, K.A., Grina, J., Laird, E.R., Buckmelter, A.J., Hansen, J.D., Newhouse, B., Moreno, D., Wenglowsky, S., Dinkel, V., Gloor, S.L., Hastings, G., Rana, S., Rasor, K., Risom, T., Sturgis, H.L., Voegtli, W.C., Mathieu, S. Bioorg.Med.Chem.Lett.
Header	Transferase/Transferase Inhibitor
Released	2012-03-13
Resolution	3.600
CATH Insert Date	27 May, 2012

PDB Images (7)

Image of CATH 4e4x

4e4x

PDB 4e4x

Image of CATH 4e4xA

4e4xA

PDB Chain 4e4xA

Image of CATH 4e4xB

4e4xB

PDB Chain 4e4xB

Image of CATH 4e4xA01

4e4xA01

CATH Domain 4e4xA01

Image of CATH 4e4xA02

4e4xA02

CATH Domain 4e4xA02

Image of CATH 4e4xB01

4e4xB01

CATH Domain 4e4xB01

Image of CATH 4e4xB02

4e4xB02

CATH Domain 4e4xB02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	28 May, 2012	Chopped
B	28 May, 2012	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4e4xA01	08 Jun, 2012	3.30.200.20	Assigned
4e4xA02	08 Jun, 2012	1.10.510.10	Assigned
4e4xB01	08 Jun, 2012	3.30.200.20	Assigned
4e4xB02	08 Jun, 2012	1.10.510.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
P15056	BRAF_HUMAN	Homo sapiens	Serine/threonine-protein kinase B-raf
P15056	BRAF_HUMAN	Homo sapiens	Serine/threonine-protein kinase B-raf