PDB 4e4m

PDB Information

PDB4E4M
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors.
Kulagowski, J.J., Blair, W., Bull, R.J., Chang, C., Deshmukh, G., Dyke, H.J., Eigenbrot, C., Ghilardi, N., Gibbons, P., Harrison, T.K., Hewitt, P.R., Liimatta, M., Hurley, C.A., Johnson, A., Johnson, T., Kenny, J.R., Bir Kohli, P., Maxey, R.J., Mendonca, R., Mortara, K., Murray, J., Narukulla, R., Shia, S., Steffek, M., Ubhayakar, S., Ultsch, M., van Abbema, A., Ward, S.I., Waszkowycz, B., Zak, M.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2012-03-13
Resolution2.250
CATH Insert Date03 Jun, 2012

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 03 Jun, 2012 Chopped
B 03 Jun, 2012 Chopped
D 03 Jun, 2012 Chopped
E 03 Jun, 2012 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4e4mA01 08 Jun, 2012 3.30.200.20 Assigned
4e4mA02 08 Jun, 2012 1.10.510.10 Assigned
4e4mB01 08 Jun, 2012 3.30.200.20 Assigned
4e4mB02 08 Jun, 2012 1.10.510.10 Assigned
4e4mD01 08 Jun, 2012 3.30.200.20 Assigned
4e4mD02 08 Jun, 2012 1.10.510.10 Assigned
4e4mE01 08 Jun, 2012 3.30.200.20 Assigned
4e4mE02 08 Jun, 2012 1.10.510.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
O60674 JAK2_HUMAN Homo sapiens Tyrosine-protein kinase JAK2
O60674 JAK2_HUMAN Homo sapiens Tyrosine-protein kinase JAK2
O60674 JAK2_HUMAN Homo sapiens Tyrosine-protein kinase JAK2
O60674 JAK2_HUMAN Homo sapiens Tyrosine-protein kinase JAK2