PDB 4djy

PDB Information

PDB4DJY
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor.
Cumming, J.N., Smith, E.M., Wang, L., Misiaszek, J., Durkin, J., Pan, J., Iserloh, U., Wu, Y., Zhu, Z., Strickland, C., Voigt, J., Chen, X., Kennedy, M.E., Kuvelkar, R., Hyde, L.A., Cox, K., Favreau, L., Czarniecki, M.F., Greenlee, W.J., McKittrick, B.A., Parker, E.M., Stamford, A.W.
Bioorg.Med.Chem.Lett.
HeaderHydrolase/Hydrolase Inhibitor
Released2012-02-02
Resolution1.860
CATH Insert Date27 May, 2012

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 28 May, 2012 Chopped
B 28 May, 2012 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4djyA01 08 Jun, 2012 2.40.70.10 Assigned
4djyA02 08 Jun, 2012 2.40.70.10 Assigned
4djyB01 08 Jun, 2012 2.40.70.10 Assigned
4djyB02 08 Jun, 2012 2.40.70.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1