PDB 4d8c

PDB Links
Overview

PDB Information

PDB	4D8C
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of cyclic sulfone hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides Rueeger, H., Lueoend, R., Rogel, O., Rondeau, J.M., Mobitz, H., Machauer, R., Jacobson, L., Staufenbiel, M., Desrayaud, S., Neumann, U. J.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2012-01-10
Resolution	2.070
CATH Insert Date	02 Dec, 2012

PDB Images (10)

Image of CATH 4d8c

4d8c

PDB 4d8c

Image of CATH 4d8cA

4d8cA

PDB Chain 4d8cA

Image of CATH 4d8cB

4d8cB

PDB Chain 4d8cB

Image of CATH 4d8cC

4d8cC

PDB Chain 4d8cC

Image of CATH 4d8cA01

4d8cA01

CATH Domain 4d8cA01

Image of CATH 4d8cA02

4d8cA02

CATH Domain 4d8cA02

Image of CATH 4d8cB01

4d8cB01

CATH Domain 4d8cB01

Image of CATH 4d8cB02

4d8cB02

CATH Domain 4d8cB02

Image of CATH 4d8cC01

4d8cC01

CATH Domain 4d8cC01

Image of CATH 4d8cC02

4d8cC02

CATH Domain 4d8cC02

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	31 Dec, 2012	Chopped
B	31 Dec, 2012	Chopped
C	31 Dec, 2012	Chopped

CATH Domains (6)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4d8cA01	03 Jan, 2013	2.40.70.10	Assigned
4d8cA02	03 Jan, 2013	2.40.70.10	Assigned
4d8cB01	03 Jan, 2013	2.40.70.10	Assigned
4d8cB02	03 Jan, 2013	2.40.70.10	Assigned
4d8cC01	03 Jan, 2013	2.40.70.10	Assigned
4d8cC02	03 Jan, 2013	2.40.70.10	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1