PDB 4d83

PDB Links
Overview

PDB Information

PDB	4D83
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of cyclic sulfone hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides Rueeger, H., Lueoend, R., Rogel, O., Rondeau, J.M., Mobitz, H., Machauer, R., Jacobson, L., Staufenbiel, M., Desrayaud, S., Neumann, U. J.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2012-01-10
Resolution	2.400
CATH Insert Date	02 Dec, 2012

PDB Images (10)

Image of CATH 4d83

4d83

PDB 4d83

Image of CATH 4d83A

4d83A

PDB Chain 4d83A

Image of CATH 4d83B

4d83B

PDB Chain 4d83B

Image of CATH 4d83C

4d83C

PDB Chain 4d83C

Image of CATH 4d83A01

4d83A01

CATH Domain 4d83A01

Image of CATH 4d83A02

4d83A02

CATH Domain 4d83A02

Image of CATH 4d83B01

4d83B01

CATH Domain 4d83B01

Image of CATH 4d83B02

4d83B02

CATH Domain 4d83B02

Image of CATH 4d83C01

4d83C01

CATH Domain 4d83C01

Image of CATH 4d83C02

4d83C02

CATH Domain 4d83C02

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	31 Dec, 2012	Chopped
B	31 Dec, 2012	Chopped
C	31 Dec, 2012	Chopped

CATH Domains (6)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4d83A01	03 Jan, 2013	2.40.70.10	Assigned
4d83A02	03 Jan, 2013	2.40.70.10	Assigned
4d83B01	03 Jan, 2013	2.40.70.10	Assigned
4d83B02	03 Jan, 2013	2.40.70.10	Assigned
4d83C01	03 Jan, 2013	2.40.70.10	Assigned
4d83C02	03 Jan, 2013	2.40.70.10	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1