PDB 4bbe

PDB Information

PDB4BBE
MethodX-RAY DIFFRACTION
Host OrganismSPODOPTERA FRUGIPERDA
Gene SourceHOMO SAPIENS
Primary Citation
Sar and in Vivo Evaluation of 4-Aryl-2-Aminoalkylpyrimidines as Potent and Selective Janus Kinase 2 (Jak2) Inhibitors
Forsyth, T., Kearney, P.C., Kim, B.G., Johnson, H.W.B., Aay, N., Arcalas, A., Brown, D.S., Chan, V., Chen, J., Du, H., Epshteyn, S., Galan, A.A., Huynh, T.P., Ibrahim, M.A., Kane, B., Koltun, E., Mann, G., Meyr, L.E., Lee, M.S., Lewis, G.L., Noguchi, R.T., Pack, M., Ridgway, B.H., Shi, X., Takeuchi, C.S., Zu, P., Leahy, J.W., Nuss, J.M., Aoyama, R., Engst, S., Gendreau, S.B., Kassees, R., Li, J., Lin, S.-H., Martini, J.-F., Stout, T., Tong, P., Woolfrey, J., Zhang, W., Yu, P.
Bioorg.Med.Chem.Lett.
HeaderTransferase
Released2012-09-21
Resolution1.900
CATH Insert Date02 Dec, 2012

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 31 Dec, 2012 Chopped
B 31 Dec, 2012 Chopped
C 31 Dec, 2012 Chopped
D 31 Dec, 2012 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4bbeA01 03 Jan, 2013 3.30.200.20 Assigned
4bbeA02 03 Jan, 2013 1.10.510.10 Assigned
4bbeB01 02 Jan, 2013 3.30.200.20 Assigned
4bbeB02 02 Jan, 2013 1.10.510.10 Assigned
4bbeC01 02 Jan, 2013 3.30.200.20 Assigned
4bbeC02 02 Jan, 2013 1.10.510.10 Assigned
4bbeD01 03 Jan, 2013 3.30.200.20 Assigned
4bbeD02 03 Jan, 2013 1.10.510.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
O60674 JAK2_HUMAN Homo sapiens Tyrosine-protein kinase JAK2
O60674 JAK2_HUMAN Homo sapiens Tyrosine-protein kinase JAK2
O60674 JAK2_HUMAN Homo sapiens Tyrosine-protein kinase JAK2
O60674 JAK2_HUMAN Homo sapiens Tyrosine-protein kinase JAK2