PDB 4b00

PDB Information

PDB4B00
MethodX-RAY DIFFRACTION
Host OrganismESCHERICHIA COLI
Gene SourceHOMO SAPIENS
Primary Citation
Design and synthesis of beta-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction of beta-amyloid peptides.
Swahn, B.M., Kolmodin, K., Karlstrom, S., von Berg, S., Soderman, P., Holenz, J., Berg, S., Lindstrom, J., Sundstrom, M., Turek, D., Kihlstrom, J., Slivo, C., Andersson, L., Pyring, D., Rotticci, D., Ohberg, L., Kers, A., Bogar, K., von Kieseritzky, F., Bergh, M., Olsson, L.L., Janson, J., Eketjall, S., Georgievska, B., Jeppsson, F., Falting, J.
J. Med. Chem.
HeaderHydrolase
Released2012-06-27
Resolution1.830
CATH Insert Date04 Nov, 2012

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 05 Nov, 2012 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4b00A01 10 Nov, 2012 2.40.70.10 Assigned
4b00A02 10 Nov, 2012 2.40.70.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1