PDB 4aqc

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Overview

PDB Information

PDB	4AQC
Method	X-RAY DIFFRACTION
Host Organism	SPODOPTERA FRUGIPERDA
Gene Source	HOMO SAPIENS
Primary Citation	A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-A]Pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of Cep-33779. Dugan, B.J., Gingrich, D.E., Mesaros, E.F., Milkiewicz, K.L., Curry, M.A., Zulli, A.L., Dobrzanski, P., Serdikoff, C., Jan, M., Angeles, T.S., Albom, M.S., Mason, J.L., Aimone, L.D., Meyer, S.L., Huang, Z., Wells-Knecht, K.J., Ator, M.A., Ruggeri, B.A., Dorsey, B.D. J.Med.Chem.
Header	Transferase
Released	2012-04-16
Resolution	1.900
CATH Insert Date	27 May, 2012

PDB Images (7)

Image of CATH 4aqc

4aqc

PDB 4aqc

Image of CATH 4aqcA

4aqcA

PDB Chain 4aqcA

Image of CATH 4aqcB

4aqcB

PDB Chain 4aqcB

Image of CATH 4aqcA01

4aqcA01

CATH Domain 4aqcA01

Image of CATH 4aqcA02

4aqcA02

CATH Domain 4aqcA02

Image of CATH 4aqcB01

4aqcB01

CATH Domain 4aqcB01

Image of CATH 4aqcB02

4aqcB02

CATH Domain 4aqcB02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	28 May, 2012	Chopped
B	28 May, 2012	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4aqcA01	08 Jun, 2012	3.30.200.20	Assigned
4aqcA02	08 Jun, 2012	1.10.510.10	Assigned
4aqcB01	08 Jun, 2012	3.30.200.20	Assigned
4aqcB02	08 Jun, 2012	1.10.510.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
O60674	JAK2_HUMAN	Homo sapiens	Tyrosine-protein kinase JAK2
O60674	JAK2_HUMAN	Homo sapiens	Tyrosine-protein kinase JAK2