PDB Information

PDB3TL5
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer.
Sutherlin, D.P., Bao, L., Berry, M., Castanedo, G., Chuckowree, I., Dotson, J., Folks, A., Friedman, L., Goldsmith, R., Gunzner, J., Heffron, T., Lesnick, J., Lewis, C., Mathieu, S., Murray, J., Nonomiya, J., Pang, J., Pegg, N., Prior, W.W., Rouge, L., Salphati, L., Sampath, D., Tian, Q., Tsui, V., Wan, N.C., Wang, S., Wei, B., Wiesmann, C., Wu, P., Zhu, B.Y., Olivero, A.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2011-08-29
Resolution2.790
CATH Insert Date06 Nov, 2011

PDB Images (7)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 29 Nov, 2011 Chopped

CATH Domains (5)

Domain ID Date inserted into CATH Superfamily CATH Status
3tl5A01 04 Sep, 2013 3.10.20.90 Assigned
3tl5A02 04 Sep, 2013 2.60.40.150 Assigned
3tl5A03 04 Sep, 2013 1.25.40.70 Assigned
3tl5A04 04 Sep, 2013 3.30.1010.10 Assigned
3tl5A05 04 Sep, 2013 1.10.1070.11 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P48736 PK3CG_HUMAN Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform