PDB Information

PDB3TJP
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
The Identification of 5-(2,4-dimorpholinopyrimidin-6-yl)-4-(trifluoromethyl)pyridin-2-amine (NVP-BKM120) as a Potent, Selective and Orally Bioavailable Class I PI3 Kinase Inhibitor for the Treatment of Cancer
Burger, M.T., Pecchi, S., Wagman, A., Ni, Z.-J., Knapp, M.S., Hendrickson, T., Atallah, G., Pfister, K., Yanchen, Z., Bartulis, S., Frazier, K., Ng, S., Smith, A., Verhagen, J., Haznedar, J., Huh, K., Iwanowicz, E., Xin, X., Menezes, D., Merritt, H., Lee, I., Weisman, M., Kaufman, S., Crawford, K., Chin, M., Bussiere, D., Shoemaker, K., Zaror, I., Maira, M., Voliva, C.
To be Published
HeaderTransferase/Transferase Inhibitor
Released2011-08-24
Resolution2.700
CATH Insert Date04 Nov, 2012

PDB Images (7)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 05 Nov, 2012 Chopped

CATH Domains (5)

Domain ID Date inserted into CATH Superfamily CATH Status
3tjpA01 10 Nov, 2012 3.10.20.90 Assigned
3tjpA02 10 Nov, 2012 2.60.40.150 Assigned
3tjpA03 10 Nov, 2012 1.25.40.70 Assigned
3tjpA04 10 Nov, 2012 3.30.1010.10 Assigned
3tjpA05 10 Nov, 2012 1.10.1070.11 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P48736 PK3CG_HUMAN Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
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