PDB 3sfk

PDB Information

PDB3SFK
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourcePlasmodium falciparum 3D7
Primary Citation
Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential.
Coteron, J.M., Marco, M., Esquivias, J., Deng, X., White, K.L., White, J., Koltun, M., El Mazouni, F., Kokkonda, S., Katneni, K., Bhamidipati, R., Shackleford, D.M., Angulo-Barturen, I., Ferrer, S.B., Jimenez-Diaz, M.B., Gamo, F.J., Goldsmith, E.J., Charman, W.N., Bathurst, I., Floyd, D., Matthews, D., Burrows, J.N., Rathod, P.K., Charman, S.A., Phillips, M.A.
J.Med.Chem.
HeaderOxidoreductase/Oxidoreductase Inhibitor
Released2011-06-13
Resolution2.950
CATH Insert Date24 Jul, 2011

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 25 Jul, 2011 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
3sfkA00 04 Aug, 2011 3.20.20.70 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q08210 PYRD_PLAF7 Plasmodium falciparum 3D7 Dihydroorotate dehydrogenase (quinone), mitochondrial