PDB 3rkz

PDB Information

PDB3RKZ
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model.
Zapf, C.W., Bloom, J.D., Li, Z., Dushin, R.G., Nittoli, T., Otteng, M., Nikitenko, A., Golas, J.M., Liu, H., Lucas, J., Boschelli, F., Vogan, E., Olland, A., Johnson, M., Levin, J.I.
Bioorg.Med.Chem.Lett.
HeaderChaperone/Chaperone Inhibitor
Released2011-04-18
Resolution1.570
CATH Insert Date24 Jul, 2011

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 01 Aug, 2011 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
3rkzA00 31 Aug, 2013 3.30.565.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P07900 HS90A_HUMAN Homo sapiens Heat shock protein HSP 90-alpha
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