PDB 3r2f

PDB Information

PDB3R2F
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Monosubstituted {gamma}-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of {beta}-secretase (BACE).
Boy, K.M., Guernon, J.M., Shi, J., Toyn, J.H., Meredith, J.E., Barten, D.M., Burton, C.R., Albright, C.F., Marcinkeviciene, J., Good, A.C., Tebben, A.J., Muckelbauer, J.K., Camac, D.M., Lentz, K.A., Bronson, J.J., Olson, R.E., Macor, J.E., Thompson, L.A.
Bioorg.Med.Chem.Lett.
HeaderHydrolase/Hydrolase Inhibitor
Released2011-03-14
Resolution2.530
CATH Insert Date04 Sep, 2011

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 05 Sep, 2011 Chopped
B 05 Sep, 2011 Chopped
D 05 Sep, 2011 Chopped
E 05 Sep, 2011 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
3r2fA01 07 Sep, 2011 2.40.70.10 Assigned
3r2fA02 07 Sep, 2011 2.40.70.10 Assigned
3r2fB01 07 Sep, 2011 2.40.70.10 Assigned
3r2fB02 07 Sep, 2011 2.40.70.10 Assigned
3r2fD01 07 Sep, 2011 2.40.70.10 Assigned
3r2fD02 07 Sep, 2011 2.40.70.10 Assigned
3r2fE01 07 Sep, 2011 2.40.70.10 Assigned
3r2fE02 07 Sep, 2011 2.40.70.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
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