Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: improving selectivity over hERG.
Rankovic, Z., Cai, J., Kerr, J., Fradera, X., Robinson, J., Mistry, A., Finlay, W., McGarry, G., Andrews, F., Caulfield, W., Cumming, I., Dempster, M., Waller, J., Arbuckle, W., Anderson, M., Martin, I., Mitchell, A., Long, C., Baugh, M., Westwood, P., Kinghorn, E., Jones, P., Uitdehaag, J.C., van Zeeland, M., Potin, D., Saniere, L., Fouquet, A., Chevallier, F., Deronzier, H., Dorleans, C., Nicolai, E.
Bioorg.Med.Chem.Lett.