PDB 3i81

PDB Information

PDB3I81
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.
Wittman, M.D., Carboni, J.M., Yang, Z., Lee, F.Y., Antman, M., Attar, R., Balimane, P., Chang, C., Chen, C., Discenza, L., Frennesson, D., Gottardis, M.M., Greer, A., Hurlburt, W., Johnson, W., Langley, D.R., Li, A., Li, J., Liu, P., Mastalerz, H., Mathur, A., Menard, K., Patel, K., Sack, J., Sang, X., Saulnier, M., Smith, D., Stefanski, K., Trainor, G., Velaparthi, U., Zhang, G., Zimmermann, K., Vyas, D.M.
J.Med.Chem.
HeaderHormone
Released2009-07-09
Resolution2.080
CATH Insert Date24 Dec, 2009

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 25 Dec, 2009 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
3i81A01 14 Mar, 2010 3.30.200.20 Assigned
3i81A02 14 Mar, 2010 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P08069 IGF1R_HUMAN Homo sapiens Insulin-like growth factor 1 receptor