PDB Information

PDB3FUL
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis.
Sandanayaka, V., Mamat, B., Mishra, R.K., Winger, J., Krohn, M., Zhou, L.M., Keyvan, M., Enache, L., Sullins, D., Onua, E., Zhang, J., Halldorsdottir, G., Sigthorsdottir, H., Thorlaksdottir, A., Sigthorsson, G., Thorsteinnsdottir, M., Davies, D.R., Stewart, L.J., Zembower, D.E., Andresson, T., Kiselyov, A.S., Singh, J., Gurney, M.E.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2009-01-14
Resolution2.390
CATH Insert Date07 Jan, 2010

PDB Images (6)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 08 Jan, 2010 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
3fulA01 17 Jan, 2010 2.60.40.1730 Assigned
3fulA02 17 Jan, 2010 3.30.2010.30 Assigned
3fulA03 17 Jan, 2010 1.10.390.10 Assigned
3fulA04 17 Jan, 2010 1.25.40.320 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P09960 LKHA4_HUMAN Homo sapiens Leukotriene A-4 hydrolase