PDB 3f5p

PDB Information

PDB3F5P
MethodX-RAY DIFFRACTION
Host OrganismHomo sapiens
Gene SourceHomo sapiens
Primary Citation
Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment
Miller, L.M., Mayer, S.C., Berger, D.M., Boschelli, D.H., Boschelli, F., Di, L., Du, X., Dutia, M., Floyd, M.B., Johnson, M., Kenny, C.H., Krishnamurthy, G., Moy, F., Petusky, S., Tkach, D., Torres, N., Wu, B., Xu, W.
Bioorg.Med.Chem.Lett.
HeaderTransferase
Released2008-11-04
Resolution2.900
CATH Insert Date01 Jan, 2009

PDB Images (49)

PDB Prints

PDB Chains (16)

Chain ID Date inserted into CATH CATH Status
A 01 Jan, 2009 Chopped
B 01 Jan, 2009 Chopped
C 01 Jan, 2009 Chopped
D 01 Jan, 2009 Chopped
E 01 Jan, 2009 Chopped
F 01 Jan, 2009 Chopped
G 01 Jan, 2009 Chopped
H 01 Jan, 2009 Chopped
I 01 Jan, 2009 Chopped
J 01 Jan, 2009 Chopped
K 01 Jan, 2009 Chopped
L 01 Jan, 2009 Chopped
M 01 Jan, 2009 Chopped
R 01 Jan, 2009 Chopped
S 01 Jan, 2009 Chopped
T 01 Jan, 2009 Chopped

CATH Domains (32)

Domain ID Date inserted into CATH Superfamily CATH Status
3f5pA01 01 Apr, 2009 3.30.200.20 Assigned
3f5pA02 01 Apr, 2009 1.10.510.10 Assigned
3f5pB01 01 Apr, 2009 3.30.200.20 Assigned
3f5pB02 01 Apr, 2009 1.10.510.10 Assigned
3f5pC01 01 Apr, 2009 3.30.200.20 Assigned
3f5pC02 01 Apr, 2009 1.10.510.10 Assigned
3f5pD01 01 Apr, 2009 3.30.200.20 Assigned
3f5pD02 01 Apr, 2009 1.10.510.10 Assigned
3f5pE01 01 Apr, 2009 3.30.200.20 Assigned
3f5pE02 01 Apr, 2009 1.10.510.10 Assigned
3f5pF01 01 Apr, 2009 3.30.200.20 Assigned
3f5pF02 01 Apr, 2009 1.10.510.10 Assigned
3f5pG01 01 Apr, 2009 3.30.200.20 Assigned
3f5pG02 01 Apr, 2009 1.10.510.10 Assigned
3f5pH01 01 Apr, 2009 3.30.200.20 Assigned
3f5pH02 01 Apr, 2009 1.10.510.10 Assigned
3f5pI01 01 Apr, 2009 3.30.200.20 Assigned
3f5pI02 01 Apr, 2009 1.10.510.10 Assigned
3f5pJ01 01 Apr, 2009 3.30.200.20 Assigned
3f5pJ02 01 Apr, 2009 1.10.510.10 Assigned
3f5pK01 01 Apr, 2009 3.30.200.20 Assigned
3f5pK02 01 Apr, 2009 1.10.510.10 Assigned
3f5pL01 01 Apr, 2009 3.30.200.20 Assigned
3f5pL02 01 Apr, 2009 1.10.510.10 Assigned
3f5pM01 01 Apr, 2009 3.30.200.20 Assigned
3f5pM02 01 Apr, 2009 1.10.510.10 Assigned
3f5pR01 01 Apr, 2009 3.30.200.20 Assigned
3f5pR02 01 Apr, 2009 1.10.510.10 Assigned
3f5pS01 01 Apr, 2009 3.30.200.20 Assigned
3f5pS02 01 Apr, 2009 1.10.510.10 Assigned
3f5pT01 01 Apr, 2009 3.30.200.20 Assigned
3f5pT02 01 Apr, 2009 1.10.510.10 Assigned

UniProtKB Entries (16)

Accession Gene ID Taxon Description
P08069 IGF1R_HUMAN Homo sapiens Insulin-like growth factor 1 receptor
P08069 IGF1R_HUMAN Homo sapiens Insulin-like growth factor 1 receptor
P08069 IGF1R_HUMAN Homo sapiens Insulin-like growth factor 1 receptor
P08069 IGF1R_HUMAN Homo sapiens Insulin-like growth factor 1 receptor
P08069 IGF1R_HUMAN Homo sapiens Insulin-like growth factor 1 receptor
P08069 IGF1R_HUMAN Homo sapiens Insulin-like growth factor 1 receptor
P08069 IGF1R_HUMAN Homo sapiens Insulin-like growth factor 1 receptor
P08069 IGF1R_HUMAN Homo sapiens Insulin-like growth factor 1 receptor
P08069 IGF1R_HUMAN Homo sapiens Insulin-like growth factor 1 receptor
P08069 IGF1R_HUMAN Homo sapiens Insulin-like growth factor 1 receptor
P08069 IGF1R_HUMAN Homo sapiens Insulin-like growth factor 1 receptor
P08069 IGF1R_HUMAN Homo sapiens Insulin-like growth factor 1 receptor
P08069 IGF1R_HUMAN Homo sapiens Insulin-like growth factor 1 receptor
P08069 IGF1R_HUMAN Homo sapiens Insulin-like growth factor 1 receptor
P08069 IGF1R_HUMAN Homo sapiens Insulin-like growth factor 1 receptor
P08069 IGF1R_HUMAN Homo sapiens Insulin-like growth factor 1 receptor